Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy, Toxicity Testing, and Personalized Medicine in Human Health, Aging and Associated Diseases (UG3/UH3 Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- RFA-TR-24-025
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $750,000
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- For Profit Organizations
- State Governments
- Higher Education Inst. (Private)
- Special District Governments
- Other
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- 501(c)(3) Nonprofits
- City/Township Governments
- Public or Indian Housing Auth.
- Independent School Districts
- Small Businesses
- Tribal Governments (Federally Recognized)
- County Governments
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
This federal grant opportunity, titled "Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy, Toxicity Testing, and Personalized Medicine in Human Health, Aging and Associated Diseases (UG3/UH3 Clinical Trial Not Allowed)," is seeking the development of multi-organ automated microphysiological systems (MPS) to study the effects of microgravity conditions on the human body in low Earth orbit at the International Space Station National Laboratory. The purpose is to provide insights on human patho(physiology), especially aging-related functional decline and age-related diseases. The Department of Health and Human Services National Institutes of Health is the sponsoring agency, with the Aging Research (CFDA 93.866) and National Center for Advancing Translational Sciences (CFDA 93.350) federal grant programs assigned. The opportunity is open to a wide range of applicant types, including non-profits, for-profit organizations, and higher education institutions.
Recent federal grant awards under the Aging Research program have ranged from $35,000 to over $2 million, with project periods typically spanning 2-5 years. The NCATS program has provided awards ranging from smaller exploratory grants of around $150,000 to larger multi-year cooperative agreements exceeding $10 million, with typical durations of 1-7 years. The proposed work is expected to be performed at the applicant institutions across the United States, with potential for multi-site collaborations.
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to develop multi-organ automated microphysiological systems (MPS) for studying the effects of microgravity conditions on human body in low Earth orbit at the International Space Station National Laboratory (ISS-NL). This program will provide insights on human patho(physiology), especially aging-related functional decline and age-related diseases. The multi-organ MPS configuration will allow better modeling of the whole organism. Improved automation with extended longevity of MPS will facilitate longer experiments in space and the collection of more physiologically relevant data. The inclusion of samples representing the broad spectrum of diversity in the human population will allow for better modeling of aging progression and development of interventions.
Files
| File | Type | Posted |
|---|---|---|
| RFA-TR-24-025-Full-Announcement.html | HTML file |
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