RFA-TR-24-025-Full-Announcement.html

This document is a Request for Application (RFA) for the federal grant opportunity titled "Tissue Chips in Space 2.0: Translational Multi-Organ Tissue Chip Systems for Drug Efficacy, Toxicity Testing, and Personalized Medicine in Human Health, Aging and Associated Diseases (UG3/UH3 Clinical Trial Not Allowed)."

The purpose of this NOFO is to develop multi-organ automated microphysiological systems (MPS) to study the effects of microgravity conditions on the human body in low Earth orbit at the International Space Station National Laboratory. This program aims to provide insights on human patho(physiology), especially aging-related functional decline and age-related diseases. The MPS configuration will allow better modeling of the whole organism, and improved automation with extended longevity will facilitate longer experiments in space. The inclusion of samples representing the diversity in the human population will enable better modeling of aging progression and development of interventions. This grant opportunity is sponsored by the Department of Health and Human Services National Institutes of Health and is assigned to the Aging Research (CFDA 93.866) and National Center for Advancing Translational Sciences (CFDA 93.350) federal grant programs.