Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2
Forecasted Federal grant Posted
- Opportunity number
- RFA-DA-28-001
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Up to $1,000,000
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Private)
- County Governments
- State Governments
- 501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- Other
- Public or Indian Housing Auth.
- Non-501(c)(3) Nonprofits
- Special District Governments
- Higher Education Inst. (Public)
- Independent School Districts
- For Profit Organizations
- City/Township Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Drug Abuse (NIDA) seeks applicants for the Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2, a cooperative agreement opportunity with no stated application deadline in the source material. This Phase 2 program builds on NIDA-funded Phase 1 work generating single-nucleus datasets from human and animal postmortem brain tissue under conditions of HIV infection, antiretroviral therapy, and substance exposure.
Eligible applicants include higher education institutions (public and private), state and local governments, federally recognized and other tribal governments and organizations, small businesses, 501(c)(3) and non-501(c)(3) nonprofits, city and township governments, county governments, special district governments, independent school districts, public or Indian housing authorities, faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
NIDA encourages research addressing substance use disorder and HIV disease interactions at subcellular, cellular, or circuit levels in the central nervous system. Priority areas include single-cell approaches such as RNA splicing interrogation, non-coding RNA analysis, epigenomic and proteomic characterization, spatial interactions, cell-cell communication, and cellular connectivity. Research may combine data mining studies to identify candidate mechanisms or targets with hypothesis-driven functional studies. The program aims to advance mechanistic understanding of substance use disorders and HIV in the central nervous system and identify novel therapeutic targets.
Awards operate under CFDA 93.279 (Drug Use and Addiction Research Programs). Standard NIH project periods typically do not exceed five years. Scientific and technical merit, research feasibility, contribution to national drug abuse problems, and relevance to NIDA priorities guide funding decisions.
Forecast synopsis
NIDA seeks to further advance its mission in the area of single cell biology. Since 2020, the NIDA-funded Single Cell Opioid Responses in the Context of HIV (SCORCH) consortium has generated single-nucleus datasets from human and animal postmortem brain tissue under conditions of HIV infection, antiretroviral therapy (ART), and/or substance exposure (e.g. opioids, cocaine, methamphetamine, and cannabinoids). Building on this Phase 1 foundation, NIDA will encourage research addressing critical questions on Substance Use Disorder (SUD) and interactions with HIV disease progression at the subcellular, cellular, or circuit levels in the Central Nervous System (CNS). Many new cutting-edge single cell approaches (e.g. interrogation of RNA splicing, non-coding RNAs, epigenomic or proteomic features, subcellular or synaptic localization and function, spatial interactions, cell-cell communication, or cellular connectivity) now enable novel hypothesis-generating studies. Along with data mining studies to identify candidate mechanisms or targets contributing to HIV/SUD interactions and hypothesis-driven studies to assess functional significance, we expect SCORCH Phase 2 to significantly advance our mechanistic understanding of SUDs and HIV in the CNS and identify targets for novel therapies. Grant authorities that allow NIDA to forecast this opportunity are 42 U.S.C. §§ 241 and 284
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
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