Predictive Science is potentially applicable to a variety of fields, including nuclear weapons, efficient manufacturing, biological systems, nanoscale material science, organic chemical processes, climate modeling, etc. Success in these simulations requires both software and algorithmic frameworks for integrating multiple disciplines into a single application and adding significant disciplinary strength and depth to make that integration effective. Applications should conduct computer science research in areas that will contribute to the advancement of Exascale computing technologies and demonstrate the results in the context of the chosen application. The FOA contains topics that are of particular interest to the NNSA National Laboratories as they move towards Exascale computing. Other topics that will enable the advancements in Exascale computing are encouraged as well. More details are contained in the FOA.