NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-052
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- City/Township Governments
- State Governments
- Public or Indian Housing Auth.
- Independent School Districts
- Tribal Organizations (Not Federally Recognized)
- Higher Education Inst. (Public)
- Small Businesses
- Special District Governments
- For Profit Organizations
- County Governments
- Other
- 501(c)(3) Nonprofits
- Non-501(c)(3) Nonprofits
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health National Institute of Neurological Disorders and Stroke (NINDS) is soliciting applications for clinical trials and biomarker studies supporting stroke treatment, recovery, and prevention through the NIH StrokeNet infrastructure, with applications due November 19, 2026.
Eligible applicants include 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, state and local governments, tribal governments (federally and non-federally recognized), higher education institutions (public and private), independent school districts, housing authorities, special district governments, and other entity types. Non-domestic (non-U.S.) entities are not eligible to apply, though foreign components of U.S. organizations are permitted.
This cooperative agreement funds multi-site exploratory and confirmatory clinical trials focused on promising stroke interventions; biomarker or outcome measure validation studies immediately preparatory to trials; and ancillary studies adding scientific aims to active StrokeNet studies. Following peer review, NINDS will prioritize the highest-scoring studies for implementation within StrokeNet. The NIH StrokeNet National Coordinating Center will support efficient implementation, the National Data Management Center will provide statistical and data management services, and Regional Coordinating Centers and affiliated clinical sites will support recruitment, retention, and protocol implementation.
The funding opportunity falls under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). Evaluation criteria include scientific merit and significance of proposed objectives, technical adequacy of experimental design, investigator competency, facility and resource adequacy, budget necessity, and relevance to program objectives. The source does not specify award amounts, award ceiling, expected number of awards, cost share requirements, or period of performance duration.
Synopsis
This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support. The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-052-Full-Announcement.html | HTML file | |
| PKG00288839.pdf |
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