NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

Open Posted

Opportunity number
PA-25-304
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Grant
Categories
  • Education
  • Environment
  • Health
  • Income Security and Social Services
Eligible applicants
  • Tribal Organizations (Not Federally Recognized)
  • 501(c)(3) Nonprofits
  • State Governments
  • Higher Education Inst. (Public)
  • County Governments
  • For Profit Organizations
  • City/Township Governments
  • Non-501(c)(3) Nonprofits
  • Independent School Districts
  • Higher Education Inst. (Private)
  • Other
  • Small Businesses
  • Special District Governments
  • Public or Indian Housing Auth.
  • Tribal Governments (Federally Recognized)
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health is soliciting applications for exploratory and developmental research projects under the NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) program, with an application due date of January 7, 2028.

Eligible applicants include tribal organizations (both federally and non-federally recognized), 501(c)(3) and non-501(c)(3) nonprofits, state and local governments, higher education institutions (public and private), counties, cities, townships, independent school districts, special districts, public and Indian housing authorities, for-profit organizations, small businesses, and other entities including Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, faith-based and community-based organizations, regional organizations, U.S. territories and possessions, and eligible federal agencies. Foreign organizations are also eligible.

The program funds early-stage and conceptual research projects in biomedical, behavioral, and clinical research. Supported projects may involve considerable risk but are expected to lead to breakthroughs or development of novel techniques, agents, methodologies, models, or applications with potential major impact on a field. The R21 mechanism explicitly excludes clinical trial activity.

The program operates across multiple NIH institutes and centers, with funding available through multiple Assistance Listing numbers including those designated for the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, and National Center for Advancing Translational Sciences, among others.

Applications are reviewed for scientific merit through peer review, followed by secondary review by relevant national advisory councils or boards. Funding decisions are based on scientific and technical merit, program relevance, and program balance consistent with NIH priorities. Standard NIH grant policies apply, including a three-year record retention requirement and audit provisions under 2 CFR 200. The review cycle typically spans approximately ten months from application to funding decision.

Synopsis

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Files

File Type Posted
PA-25-304-Full-Announcement.html HTML file
PKG00289730.pdf PDF

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