NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
Past Federal grant forecast Posted
- Opportunity number
- RFA-DA-27-012
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications expected due
- Award size
- Up to $1,200,000
Opportunity facts
- Expected posting
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Other
- Small Businesses
- City/Township Governments
- Higher Education Inst. (Private)
- Tribal Governments (Federally Recognized)
- County Governments
- 501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- Tribal Organizations (Not Federally Recognized)
- Independent School Districts
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- State Governments
- For Profit Organizations
- Special District Governments
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health seeks applicants for the NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System, a cooperative agreement supporting development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling human brain anatomy, circuitry, cognition, behavior, and lifespan. This is a forecast opportunity with no application deadline stated.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, state and local governments, tribal governments (federally recognized and other), faith-based and community-based organizations, regional organizations, U.S. territories, foreign institutions, and eligible federal agencies.
The initiative builds on previously supported marmoset gene-editing infrastructure by integrating New Approach Methodologies (NAMs) with other models to advance understanding of human brain function and disease. High-priority research areas include autism spectrum disorders, schizophrenia, and other behavioral and developmental disorders where complex mechanisms cannot yet be captured in NAMs. Applicants must justify model selection as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function.
The opportunity operates under CFDA 93.279 (Drug Use and Addiction Research Programs), though the initiative itself focuses on neuroscience infrastructure and model development. Grant authority derives from 42 U.S.C. 241 and 284. Standard NIH review procedures apply: scientific and technical merit, feasibility, potential contribution to national research priorities, and program relevance drive evaluation. Project periods typically do not exceed five years, with eligibility for competing continuation applications prior to project termination.
Forecast synopsis
The NIH Blueprint (a consortium of NIH Institutes that support neuroscience research) seeks to advance its mission by supporting the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative will build on the previously supported marmoset gene-editing infrastructure, by integrating New Approach Methodologies (NAMs) with other models, to advance understanding of human brain function and disease, including human-derived NAMs for cross-species comparisons across development. Many mechanisms of complex conditions, such as autism spectrum disorders, schizophrenia, and other behavioral/developmental disorders, cannot yet be captured in NAMs and are therefore high priorities for research investment to accelerate development and validation of human-derived NAMs. Appropriate models should be used and clearly justified as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function. Grant authorities are as follows: 42 U.S.C 241 and 284.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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