New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-279
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Categories
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- Income Security and Social Services
- Education
- Health
- Eligible applicants
-
- Small Businesses
- Other
- County Governments
- Non-501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- Special District Governments
- Tribal Organizations (Not Federally Recognized)
- 501(c)(3) Nonprofits
- Higher Education Inst. (Public)
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- Independent School Districts
- State Governments
- City/Township Governments
- For Profit Organizations
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications for research grants to develop new approaches for measuring brain changes across extended timespans, with applications due May 7, 2027. Multidisciplinary investigators from higher education institutions, government entities, tribal organizations, nonprofits, small businesses, for-profit organizations, and other eligible categories may compete; foreign organizations and non-domestic entities are also eligible.
The funding opportunity supports research measuring brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment in healthy participants, specific clinical groups such as those with cognitive or motor challenges, and animal models. Research may focus on longitudinal neuroanatomical or functional changes at any level—genetics, genomics, single cells, connectomics, neural population activity patterns, or others—to improve repeated measures across longer epochs of the lifespan and better predict outcomes at later ages. The program emphasizes technological and conceptual innovation.
Evaluation criteria assess significance, approach, innovation, investigator qualifications and experience, scientific environment, budget appropriateness, program relevance, adequacy of plans for subject recruitment and retention (including gender and minority representation), protection of human subjects or environment, and data-sharing plans where applicable. Applications receive dual scientific review by non-NIH scientists followed by secondary review by a national advisory council or board.
The opportunity is assigned to four Assistance Listings: Child Health and Human Development Extramural Research (93.865), Discovery and Applied Research for Technological Innovations to Improve Human Health (93.286), Cancer Biology Research (93.396), and Aging Research (93.866). All accepted applications compete for available funds based on scientific merit and program balance. Standard NIH review timelines are approximately six to nine months from application to funding decision. Awards are typically for project periods not exceeding five years.
Synopsis
The purpose of this funding opportunity is to encourage multidisciplinary investigators to develop new approaches or apply existing approaches in novel ways to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment. The overarching goal is to extend our understanding of brain development and aging, including studies of the neurodevelopmental origins of later health and disease. Research can include healthy human participants of any age, specific clinical groups such as those with cognitive, motor, or affective regulation challenges, and/or animal research on these domains of function. The studies can focus on longitudinal neuroanatomical or functional changes at any level, including genetics/genomics, single cells, connectomics, neural population activity patterns, and others. This funding opportunity is intended to encourage technological and conceptual innovation to improve repeated measures across longer epochs of the lifespan, to better predict outcomes at later ages.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-279-Full-Announcement.html | HTML file | |
| PKG00289000.pdf |
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