Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- RFA-DA-28-013
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
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- 501(c)(3) Nonprofits
- City/Township Governments
- Public or Indian Housing Auth.
- Small Businesses
- Higher Education Inst. (Public)
- Special District Governments
- Higher Education Inst. (Private)
- State Governments
- County Governments
- Other
- Independent School Districts
- Tribal Governments (Federally Recognized)
- Non-501(c)(3) Nonprofits
- For Profit Organizations
- Tribal Organizations (Not Federally Recognized)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Drug Abuse (NIDA) seeks applicants for the Neural Ensembles & Used Substances (NExUS) Collaboratory cooperative agreement to build a multimodal inventory of cell ensembles encoding the effects of addictive substances, with applications due February 8, 2027. This is a non-clinical trial research program; clinical trials are not allowed.
Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments (federally recognized and non-federally recognized), Indian/Native American tribal governments, federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic entities. Foreign subawards or subcontracts are prohibited; unfunded international collaborations and foreign components are permitted.
NIDA intends to commit $4 million in fiscal year 2027 to fund multiple projects. Individual awards may not exceed $700,000 in direct costs annually over a maximum five-year project period. No cost share is required.
The collaborative operates as a cooperative agreement, entailing substantial NIH programmatic involvement including ongoing coordination through the NExUS Program Steering Committee and collaboration with NIH Project Scientists. Projects must systematically identify, map, and analyze groups of neurons responding to used substances across all drug classes (opioids, psychostimulants, cannabinoids, depressants, psychedelics, alcohol) and address five core objectives: collecting and sharing granular datasets of neural cell populations, integrating physiological readouts with multimodal data (molecular identity, epigenetic state, morphology, connectivity), developing quantitative metrics and visualization tools, developing mechanistic models for ensemble recruitment, and facilitating synergies among NExUS-funded projects and BRAIN Initiative efforts.
Applications must include a Data Management and Sharing Plan with data deposited in specified NIH repositories (NEMO-SCORCH for omics data, DANDI for neurophysiology, EMBER for multimodal data). All PD/PIs must maintain eRA Commons accounts linked to valid ORCID IDs. Linked U01 applications from separate project sites are permitted with overlapping research strategies, provided each application clearly delineates its unique contributions.
The program operates under CFDA 93.279 (Drug Use and Addiction Research Programs). The earliest start date is December 2027.
Synopsis
The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).
NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations.
This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.
Eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityForeign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Files
| File | Type | Posted |
|---|---|---|
| PKG00294341.pdf | ||
| RFA-DA-28-013-Full-Announcement.html | HTML file |
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