Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-227
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Categories
-
- Income Security and Social Services
- Health
- Eligible applicants
-
- Higher Education Inst. (Public)
- 501(c)(3) Nonprofits
- Special District Governments
- For Profit Organizations
- Tribal Organizations (Not Federally Recognized)
- State Governments
- Small Businesses
- Other
- City/Township Governments
- Non-501(c)(3) Nonprofits
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- County Governments
- Tribal Governments (Federally Recognized)
- Independent School Districts
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications to expand knowledge of the natural history of disorders screenable in newborn periods, with an application due date of January 7, 2028. The program funds research to improve understanding of biological mechanisms, genetic and clinical heterogeneity, diagnostic accuracy, and treatment development for conditions that are or may become part of statewide newborn screening programs.
Eligible applicants include higher education institutions (public and private), 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, state and local governments, tribal organizations (federally and non-federally recognized), special district governments, independent school districts, and public or Indian housing authorities. The program also welcomes applications from historically Black colleges and universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander serving institutions, faith-based or community-based organizations, tribally controlled colleges and universities, U.S. territories or possessions, and non-domestic entities.
The grant is issued under CFDA 93.865, Child Health and Human Development Extramural Research, administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Applicants must use the FORMS-I application guide and follow research-specific instructions designated for R01 applications. Applications receive dual scientific review by non-NIH scientists. Evaluation criteria assess significance of proposed research, approach, innovation, investigator qualifications, and research environment. The program funds research project grants through the standard NIH review process, with awards issued by NICHD following peer review and national advisory council recommendation.
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) encourages applications that will expand knowledge of the natural history of disorders that currently are, or may become, part of statewide newborn screening programs. A comprehensive understanding of the natural history of a condition is necessary to facilitate appropriate interventions for infants identified by newborn screening. Characterization of the sequence and timing of symptom development provides information crucial for developing targeted, age-appropriate treatments and for establishing a baseline against which to assess novel interventions. In addition, for some conditions, establishment of genotype-phenotype correlations may facilitate prediction of the clinical course; for others, identification of modifying genetic, epigenetic, or environmental factors may enhance understanding of clinical outcomes. Comprehensive data on the natural history of a condition will facilitate the fields ability to: 1) identify the underlying biological mechanisms; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the condition; 3) improve diagnostic accuracy; 4) facilitate clinical trials by providing comprehensive natural history data; 5) prevent, manage, and treat symptoms and complications of the condition; 6) furnish physicians and families with needed support and predictive information about the condition; and 7) establish data collection systems or patient registries to collect longitudinal data (e.g., child/family outcomes following newborn screening).
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-227-Full-Announcement.html | HTML file | |
| PKG00288549.pdf |
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