National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-352
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- Higher Education Inst. (Public)
- Tribal Organizations (Not Federally Recognized)
- City/Township Governments
- Special District Governments
- Other
- Tribal Governments (Federally Recognized)
- County Governments
- Non-501(c)(3) Nonprofits
- For Profit Organizations
- Public or Indian Housing Auth.
- Independent School Districts
- 501(c)(3) Nonprofits
- Small Businesses
- State Governments
- Higher Education Inst. (Private)
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications to advance discovery, preclinical development, and proof-of-concept testing of new therapeutic agents and neurostimulation approaches to treat mental disorders, substance use disorders, and alcohol use disorder, with applications due October 25, 2027. The program operates as a U01 cooperative agreement mechanism supporting discrete, specified projects; applicants seeking to fund a multidisciplinary research program with multiple interconnected projects should consider the companion U19 FOA instead.
Eligible applicants include higher education institutions (public and private), tribal governments (federally and non-federally recognized), city and county governments, state governments, special district governments, 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, public or Indian housing authorities, independent school districts, and eligible federal agencies. Tribally Controlled Colleges and Universities, Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions are also eligible. Non-domestic (non-U.S.) organizations are not eligible to apply; foreign components of U.S. organizations are allowed, but non-domestic components are not.
The program strongly encourages academia-industry partnerships. Projects must develop novel ligands and circuit-engagement devices as tools to characterize existing or validate new drug and device targets. The opportunity falls under CFDA 93.242 (Mental Health Research Grants) administered by the National Institute of Mental Health. Standard NIH project periods do not exceed five years and are subject to peer review, National Advisory Mental Health Council review, and evaluation on scientific and technical merit, program relevance, and program balance. Award specifics including ceiling, floor, and expected number of awards are not disclosed in this NOFO.
Synopsis
Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-352-Full-Announcement.html | HTML file | |
| PKG00290109.pdf |
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