PAR-25-352-Full-Announcement.html

This is a Notice of Funding Opportunity (NOFO) announcement PAR-25-352 from the Department of Health and Human Services National Institutes of Health for the National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program, reissuing PAR-20-118. The opportunity supports research for discovering and developing new therapeutic agents and neurostimulation approaches for mental disorders, substance use disorders (SUDs), and alcohol use disorder (AUD), along with developing novel ligands and circuit-engagement devices for drug/device target validation.

The funding instrument is a U01 cooperative agreement mechanism supporting discrete, specified projects. Eligible applicants include higher education institutions, small businesses, for-profit organizations, tribal entities, government entities, and both 501(c)(3) and non-501(c)(3) nonprofits. The program falls under CFDA 93.242 (Mental Health Research Grants) and emphasizes academia-industry partnerships. A companion U19 FOA is available for broader, multidisciplinary, long-term research programs with multiple projects.