Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- PAR-25-060
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Up to $750,000
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Special District Governments
- 501(c)(3) Nonprofits
- Higher Education Inst. (Private)
- State Governments
- Tribal Organizations (Not Federally Recognized)
- County Governments
- Higher Education Inst. (Public)
- Public or Indian Housing Auth.
- Tribal Governments (Federally Recognized)
- For Profit Organizations
- Other
- Small Businesses
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Independent School Districts
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health is soliciting applications for development and validation of animal models and human/animal tissue ex vivo systems to facilitate neurotherapeutic discovery, with an application due date of October 20, 2027.
Eligible applicants include higher education institutions (public and private), small businesses, for-profit organizations, nonprofits (501(c)(3) and non-501(c)(3)), state and local governments, tribal organizations (federally and non-federally recognized), special district governments, public or Indian housing authorities, independent school districts, Alaska Native and Native Hawaiian serving institutions, HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, faith-based and community-based organizations, federal agencies, regional organizations, and non-domestic entities.
The FOA funds proposals that recapitulate the phenotypic and physiologic characteristics of defined neurological or neuromuscular disorders. Models should demonstrate significant improvement in translational relevance and provide feasible, meaningful assessments of therapeutic efficacy applicable in both preclinical and clinical settings. Clinical trials are not permitted. This is part of the IGNITE program focused on early-stage drug discovery and exploratory translational efforts.
Awards are made under CFDA 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) administered by the National Institute of Neurological Disorders and Stroke. The R61/R33 mechanism structure funds early translational research. Evaluation emphasizes scientific merit, experimental design adequacy, investigator competency, facility adequacy, budget justification, and program relevance. Applications requesting $500,000 or more in direct costs in any yearly budget period require prior NINDS approval.
Synopsis
This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-060-Full-Announcement.html | HTML file | |
| PKG00288420.pdf |
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