Hermes
Closed Posted
- Opportunity number
- HR001124S0025
- Agency
-
Defense Advanced Research Projects Agency
Department of Defense
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement, Grant, Procurement Contract
- Category
-
- Science and Technology and other Research and Development
- Eligible applicants
-
- Other
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of systemic drug delivery platforms for medical countermeasures under the Hermes program. DARPA is seeking transformative approaches that enable exceptional biodistribution, endosomal escape efficiency, and minimal toxicity. Successful proposals must include details on the screening pipeline, reporter systems, immunogenicity/toxicity assessment, and the chosen therapeutic cargo. Abstracts are due by May 3, 2024, and full proposals are due by June 11, 2024. DARPA anticipates making multiple awards in the form of cooperative agreements, grants, or procurement contracts.
The Hermes program is funded under the DARPA Research and Technology Development grant program (CFDA 12.910), which supports basic, applied, and advanced research at educational institutions, nonprofit organizations, and commercial firms. The resulting delivery platforms developed under this effort will be transferred to U.S. Government stakeholders for further development, but the specific award values or budget ranges are not provided.
Synopsis
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to develop systemic drug delivery platforms for medical countermeasures (MCMs). The Hermes program is explicitly seeking transformative approaches enabling the development of delivery platforms with systemic biodistribution, exceptional endosomal escape efficiency, and minimal toxicity. Successful proposals will include a detailed description of the proposed delivery platform including 1) screening pipeline, 2) reporter systems for monitoring biodistribution and expression in animal models, 3) methods to monitor immunogenicity/toxicity, and 4) chosen therapeutic cargo and justification. Systemic delivery platforms developed under the Hermes effort will be transferred to U.S. Government stakeholders for further development.
Files
| File | Type | Posted |
|---|---|---|
| HR001124S0025-Amendment-01.pdf | ||
| HERMES_BAA_Attachment_F_DARPAStandardCostProposalSpreadsheetSingleTA.xlsx | XLSX spreadsheet | |
| HERMES_BAA_Attachment_E_Proposal_Instructions_and_Volume_II_Template__Cost.docx | DOCX document | |
| HERMES_BAA_Attachment_D_Proposal_Instructions_and_Volume_I_Template__Technical_and_Management.docx | DOCX document | |
| HERMES_BAA_Attachment_A_Abstract_Summary_Side_Template.pptx | PPTX presentation | |
| HERMES_BAA_Attachment_C_Proposal_Summary_Slide_Template.pptx | PPTX presentation | |
| HERMES_BAA_Attachment_B_Abstract_Instructions_and_Template.docx | DOCX document | |
| HR001124S0025.pdf |
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