Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)
Open Posted
- Opportunity number
- PAR-25-210
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Categories
-
- Education
- Health
- Eligible applicants
-
- Higher Education Inst. (Private)
- Tribal Governments (Federally Recognized)
- Non-501(c)(3) Nonprofits
- For Profit Organizations
- Small Businesses
- Other
- Higher Education Inst. (Public)
- State Governments
- Independent School Districts
- Public or Indian Housing Auth.
- 501(c)(3) Nonprofits
- Special District Governments
- County Governments
- Tribal Organizations (Not Federally Recognized)
- City/Township Governments
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health seeks applications for R33 grants supporting mechanistic research on precision probiotic therapies, with applications due June 2, 2027. This solicitation is restricted to advanced mechanistic studies in which host biological patterns correlated with probiotic responses have been identified through preliminary data; applicants pursuing early-stage discovery of such patterns should apply instead to the companion R61/R33 mechanism (PAR-AT-24-XXX TEMP-25412).
Eligible applicants include higher education institutions (public and private), state and local governments, tribal governments and organizations, nonprofits including 501(c)(3) entities and faith-based organizations, for-profit organizations, small businesses, independent school districts, housing authorities, and special district governments. Non-domestic (non-U.S.) entities are not eligible to apply, though foreign components of U.S. organizations are allowed.
The program funds rigorously designed mechanistic studies employing relevant or innovative animal models or human subjects to assess how unique patterns of host biology—including native microbiome composition, immune system function, gender, diet, age, genetic background, lifestyle, and health history—correlate with probiotic responses and predict clinical outcomes. Applications must demonstrate causality or predictability of identified host factors through further mechanistic investigation.
The R33 mechanism funds advanced research without mandatory cost share. Award amounts, number of awards, and period of performance are not specified in the announcement. Clinical trials are optional.
The opportunity is affiliated with multiple NIH Institutes and Centers and draws co-funding potential from the NIH Office of Research on Women's Health (CFDA 93.313), Cancer Cause and Prevention Research (93.393), Oral Diseases and Disorders Research (93.121), Research and Training in Complementary and Integrative Health (93.213), and Aging Research (93.866). Applications undergo two-stage peer review—initial scientific review by an extramural panel and secondary review by the relevant NIH advisory council. Evaluation emphasizes scientific merit, innovation, technical adequacy, investigator competency, resource sufficiency, budget justification, and relevance to program objectives.
Synopsis
The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-210-Full-Announcement.html | HTML file | |
| PKG00288344.pdf |
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