Enabling Discovery through GEnomics

Posted

Opportunity number
20-532
Agency
Applications due
Not on record
Award size
Up to $2,000,000

Opportunity facts

Assistance listings
Funding instrument
Grant
Category
  • Science and Technology and other Research and Development
Eligible applicants
  • Unrestricted
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

The Enabling Discovery through GEnomic Tools (EDGE) program, funded by the National Science Foundation (NSF), supports genomic research that investigates the mechanistic basis of complex traits in diverse organisms. The program aims to provide funding for the development of innovative tools, technologies, resources, and infrastructure to advance biological research on the connections between genes and phenotypes. Key objectives include testing cause-and-effect hypotheses between gene function and phenotypes, as well as conducting hypothesis-driven research to explore genotype-phenotype relationships in non-model organisms. Proposals will be evaluated based on their potential to uncover the fundamental rules governing genomes-to-phenomes relationships, a critical area for understanding the rules of life. The deadline for submitting proposals is September 15, 2025.

Typical awards under the NSF Biological Sciences program, which encompasses the EDGE initiative, range from $240,000 to over $1.5 million with project durations of 2-5 years. The research is expected to be conducted at academic institutions and research facilities across the United States.

Synopsis

The Enabling Discovery through GEnomic Tools (EDGE) program supports genomic research that addresses the mechanistic basis of complex traits in diverse organisms within the context (environmental, developmental, social, and/or genomic) in which they function. The EDGE program also continues to support the development of innovative tools, technologies, resources, and infrastructure that advance biological research focused on the identification of the causal mechanisms connecting genes and phenotypes. EDGE is designed to provide support for (1) the development of tools, approaches, and infrastructure aimed at testing cause and effect hypotheses between gene function and phenotypes in diverse plants, animals, microbes, viruses, or fungi for which these methods are presently unavailable, and (2) hypothesis-driven research that tests cause and effect relations between genotype(s) and phenotypes in non-model plants, animals, microbes, viruses, or fungi. These goals are essential to uncovering the rules that underlie genomes-to-phenomes relationships, an area relevant to Understanding the Rules of Life: Predicting Phenotype, one of the 10 Big Ideas for future NSF investment.

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