Dynamic and Adaptable Infrastructure for Drug Development and Outreach to Aid the Research Community in Advancing Medication Repurposing and Repositioning Efforts for Substance Use Disorders (SUDs) (U54 - Clinical Trials Not Allowed)
Closed Posted
- Opportunity number
- RFA-DA-26-020
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Categories
-
- Education
- Health
- Eligible applicants
-
- Other
- Higher Education Inst. (Private)
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Public)
- For Profit Organizations
- City/Township Governments
- Independent School Districts
- Tribal Organizations (Not Federally Recognized)
- County Governments
- State Governments
- 501(c)(3) Nonprofits
- Special District Governments
- Non-501(c)(3) Nonprofits
- Small Businesses
- Public or Indian Housing Auth.
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute on Drug Abuse (NIDA) is seeking applications to establish a dynamic drug development infrastructure center focused on substance use disorders (SUDs). The center will provide comprehensive services to academic and biotech researchers, including Target Product Profiles creation, Freedom-to-Operate analysis, intellectual property consultations, regulatory guidance, and technical pipeline support for repurposing and repositioning medications. Key qualifications for applicants include expertise in pharmacology, toxicology, neuroscience, in silico discovery, target validation, preclinical development, clinical protocol development, regulatory affairs, and intellectual property management. Evaluation criteria will likely emphasize scientific and technical merit, feasibility of research, potential contribution to addressing drug abuse, and alignment with NIDA priorities. The grant opportunity has a posted date of May 27, 2025, with a proposal due date of January 28, 2026, under the U54 activity code.
While specific funding amounts are not explicitly detailed, the Drug Use and Addiction Research Programs (CFDA 93.279) typically support projects ranging from $41,000 to $7.3 million, with project periods spanning 1-5 years. The center will be responsible for engaging the research community, soliciting proposals, and implementing processes to evaluate and advance high-quality projects addressing different SUD indications. Applicants can be from various organizational types, including higher education institutions, tribal governments, for-profit organizations, nonprofits, and government entities. The place of performance is not specifically restricted, but the center is expected to operate as a collaborative hub supporting nationwide research efforts in substance use disorder drug development.
Synopsis
This Notice of Funding Opportunity seeks applications to establish and operate a dynamic and adaptable drug development infrastructure to support the research community. The aim is to strengthen and expand the substance use disorder (SUD) drug development pipeline by accelerating the evaluation and validation of repurposed and repositioned drugs. The Center and its team of subject matter experts will provide comprehensive drug development services to academic and biotech researchers at all stages of product development. By supporting various projects that address different SUD indications, the Center will contribute to reducing the burden of SUDs on individuals and communities. The services offered will include assistance in creating Target Product Profiles, Freedom-to-Operate analysis, intellectual property consultations, regulatory guidance, and technical pipeline support. Additionally, the Center will engage in outreach efforts to connect with the research community, solicit proposals, and implement processes to evaluate, select, and advance the projects focused on repurposing and repositioning medications for SUD treatment.
Files
| File | Type | Posted |
|---|---|---|
| RFA-DA-26-020-Full-Announcement.html | HTML file |
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