Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)
Open Posted
- Opportunity number
- PAR-25-182
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- 501(c)(3) Nonprofits
- Small Businesses
- For Profit Organizations
- County Governments
- Other
- Public or Indian Housing Auth.
- Higher Education Inst. (Private)
- Higher Education Inst. (Public)
- Tribal Governments (Federally Recognized)
- State Governments
- Non-501(c)(3) Nonprofits
- Independent School Districts
- City/Township Governments
- Special District Governments
- Tribal Organizations (Not Federally Recognized)
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Mental Health is soliciting applications for psychosocial therapeutic and preventive intervention development using an R61/R33 phased clinical trial framework, with applications due October 15, 2027.
Eligible applicants include 501(c)(3) and non-501(c)(3) nonprofits, small businesses, for-profit organizations, higher education institutions (public and private), tribal governments (federally and nonfederally recognized), state and local governments, and other entities including Alaska Native and Native Hawaiian Serving Institutions, HBCUs, Hispanic-serving Institutions, Asian American Native American Pacific Islander Serving Institutions, faith-based and community-based organizations, non-domestic entities, and U.S. territories or possessions. No cost share or matching requirement is stated.
The R61 phase provides up to two years of support for target engagement evaluation and establishment of intervention parameters. The R33 phase provides up to three years of support to replicate target engagement from prior studies and test the association between target engagement and clinical outcome change. Expected number of awards and award ceiling are not specified.
The program emphasizes the experimental therapeutics approach, translating emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. Applications are evaluated for scientific and technical merit by peer review, with the National Advisory Mental Health Council also reviewing competitive applications. Funding decisions consider technical merit, program relevance, program balance, and availability of funds.
The opportunity falls under CFDA 93.242 (Mental Health Research Grants) administered by the National Institute of Mental Health.
Synopsis
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-182-Full-Announcement.html | HTML file | |
| PKG00289156.pdf |
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