PAR-25-182-Full-Announcement.html

This is a Notice of Funding Opportunity (NOFO) from the National Institute of Mental Health (NIMH) for a grant opportunity (PAR-25-182) focused on developing psychosocial therapeutic and preventive interventions for mental disorders. The funding utilizes an R61/R33 phased innovation approach requiring clinical trials.

The opportunity is open to a wide range of applicants including higher education institutions, tribal organizations, small businesses, nonprofits, and government entities. The grant provides up to two years of initial support for target engagement evaluation and intervention parameter establishment (R61 phase), followed by up to three years of support to replicate target engagement and test its association with clinical outcomes (R33 phase). The program falls under CFDA 93.242 (Mental Health Research Grants) and aims to accelerate the translation of behavioral, cognitive, affect, and neuropsychological science into practical therapeutic interventions, following NIMH's experimental therapeutics approach to intervention development.