Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)
Open Posted
- Opportunity number
- PAR-25-181
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- Tribal Governments (Federally Recognized)
- 501(c)(3) Nonprofits
- Public or Indian Housing Auth.
- City/Township Governments
- Higher Education Inst. (Public)
- Other
- Tribal Organizations (Not Federally Recognized)
- Special District Governments
- Independent School Districts
- State Governments
- Non-501(c)(3) Nonprofits
- Small Businesses
- For Profit Organizations
- Higher Education Inst. (Private)
- County Governments
- Points of contact
-
- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Mental Health is soliciting R33 grant applications for developing and testing novel psychosocial therapeutic and preventive interventions for mental disorders, with an application due date of October 15, 2027. This NOFO provides up to three years of support to replicate target engagement from prior studies and test the association between target engagement and change in clinical outcome(s).
Eligible applicants include Tribal Governments (Federally Recognized), 501(c)(3) nonprofits, public or Indian Housing Authorities, city and township governments, public and private higher education institutions, other nonprofits, tribal organizations (not federally recognized), special district governments, independent school districts, state and county governments, small businesses, for-profit organizations, Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander serving institutions, eligible federal agencies, faith-based or community-based organizations, Hispanic-serving institutions, historically Black colleges and universities, tribally controlled colleges and universities, non-domestic entities, regional organizations, and U.S. territories or possessions.
The funding mechanism is a grant operating under CFDA 93.242 (Mental Health Research Grants program). The opportunity emphasizes NIMH's experimental therapeutics approach to intervention development, accelerating translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. Applications must include clinical trial designs that align with this pipeline objective.
Award ceiling, award floor, expected number of awards, cost share requirements, place of performance, and evaluation weighting are not specified in the source material. Review will follow standard NIH peer review processes, with all applications evaluated for scientific and technical merit by appropriate scientific peer review panels and competitive applications reviewed by the National Advisory Mental Health Council.
Synopsis
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-181-Full-Announcement.html | HTML file | |
| PKG00289147.pdf |
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