PAR-25-181-Full-Announcement.html

This Notice of Funding Opportunity (NOFO) from the National Institute of Mental Health (NIMH) solicits R33 grant applications for developing and testing novel psychosocial therapeutic and preventive interventions for mental disorders. Operating under the Mental Health Research Grants program (CFDA 93.242), this opportunity (PAR-25-181) provides up to three years of funding to support clinical trials that replicate target engagement from prior studies and test associations between target engagement and clinical outcomes.

The funding opportunity is open to a broad range of applicants including state/local governments, higher education institutions, nonprofits, tribal organizations, and small businesses. Following NIMH's experimental therapeutics approach, the NOFO aims to accelerate translation of behavioral, cognitive, affect, and neuropsychological science into practical interventions. The Department of Health and Human Services National Institutes of Health (NIH) serves as the sponsoring agency for this clinical trial-focused research initiative.