Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Open Posted
- Opportunity number
- PAR-25-255
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
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- 93.399 Cancer Control
- 93.172 Human Genome Research
- 93.242 Mental Health Research Grants
- Funding instrument
- Grant
- Categories
-
- Education
- Health
- Eligible applicants
-
- Non-501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Other
- Higher Education Inst. (Public)
- Higher Education Inst. (Private)
- Special District Governments
- City/Township Governments
- County Governments
- For Profit Organizations
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- State Governments
- Independent School Districts
- Public or Indian Housing Auth.
- 501(c)(3) Nonprofits
- Points of contact
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- NIH OER Webmaster grantsinfo@nih.gov
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institutes of Health seeks applicants for novel theory and methods development enabling better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations, with applications due November 5, 2026. Clinical trials are not permitted under this mechanism (R01 Clinical Trial Not Allowed).
Eligible applicants include public and private higher education institutions, nonprofits (including 501(c)(3) and non-501(c)(3)), tribal governments and tribal organizations, state and local governments, small businesses, for-profit organizations, special district governments, and Alaska Native, Native Hawaiian, Asian American Native American Pacific Islander, Hispanic-serving, and historically Black colleges and universities. Faith-based and community-based organizations, tribally controlled colleges and universities, eligible federal agencies, regional organizations, and non-domestic entities are also eligible.
The administering institutes are the National Institute of Mental Health, National Human Genome Research Institute, and National Cancer Institute. Three CFDA numbers apply: 93.242 (Mental Health Research Grants), 93.172 (Human Genome Research), and 93.399 (Cancer Control).
Applicants must employ interdisciplinary approaches drawing from natural and social sciences that account for interdependencies across biological, social, and ecological scales, make extensive use of theory and modeling, and validate findings with available large-scale datasets. The program emphasizes methodological innovation in genetic architecture research applicable across diverse populations and complex traits.
Award structure, cost share requirements, and specific evaluation weighting are not detailed in the source materials provided. Applicants must follow Research-specific instructions designated in the application guide package and comply with standard NIH grants policy regarding financial management, record retention (minimum three years), and audit requirements under OMB 2 CFR 200.
Synopsis
The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.
Eligibility
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-255-Full-Announcement.html | HTML file | |
| PKG00288730.pdf |
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