Immune Tolerance Network (UM1 Clinical Trial Required)
Open Posted
- Opportunity number
- RFA-AI-28-005
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- 501(c)(3) Nonprofits
- Other
- City/Township Governments
- For Profit Organizations
- Tribal Governments (Federally Recognized)
- Special District Governments
- Public or Indian Housing Auth.
- Non-501(c)(3) Nonprofits
- Independent School Districts
- Higher Education Inst. (Public)
- County Governments
- Higher Education Inst. (Private)
- Small Businesses
- State Governments
- Tribal Organizations (Not Federally Recognized)
- Points of contact
Opportunity details come from Grants.gov. Updated .
About this opportunity
The National Institute of Allergy and Infectious Diseases (NIH) is soliciting applications for a single cooperative agreement to continue the Immune Tolerance Network, with applications due January 29, 2027. Only one application per institution is permitted, and a clinical trial is required. NIH intends to commit $27 million in FY 2028 to fund one award with a 7-year project period, and application budgets should not exceed $23 million per year in direct costs. Applications open December 29, 2026.
Applicant types include 501(c)(3) and non-501(c)(3) nonprofits, for-profit organizations, small businesses, public and private higher education institutions, state, county, city/township, and tribal governments, special districts, public housing authorities, and independent school districts. Other listed categories include faith-based or community-based organizations, regional organizations, and non-domestic entities (foreign institutions). Foreign subawards and subcontracts are prohibited.
The Network develops tolerogenic therapies across three clinical areas: allergic diseases and asthma, autoimmune diseases, and immune-mediated consequences of transplantation. Applicants must describe four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. The PD/PI(s) must commit a minimum of 3.6 person-months per year. Applications require a Data Management and Sharing Plan, and funded investigators must share data publicly through the Immunology Database and Analysis Portal (ImmPort).
Program-level review considers scientific merit and general significance, technical adequacy of the design, investigator competency, facilities and resources, budget necessity, and relevance to program objectives. Submission requires active System for Award Management (SAM), eRA Commons, and Grants.gov registration, with electronic submission by 5:00 PM local time on the due date. The opportunity is assigned to Assistance Listing 93.855, Allergy and Infectious Diseases Research, authorized under Sections 301 and 405 of the Public Health Service Act and 42 CFR Part 52.
Synopsis
The purpose of this notice of funding opportunity (NOFO) is to support applications to continue the Immune Tolerance Network (ITN). The primary objective of the Network is to develop tolerogenic therapies for immune-mediated disorders. The three main clinical areas of work are: 1) Allergic diseases and asthma; 2) Autoimmune diseases; and 3) Immune-mediated consequences of transplantation. The core functions of the ITN include designing, conducting, and sharing the results of clinical trials and performing integrated mechanistic studies.
Eligibility
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Files
| File | Type | Posted |
|---|---|---|
| PKG00294430.pdf | ||
| RFA-AI-28-005-Full-Announcement.html | HTML file |
On GovTribe
Work this opportunity
- Track it in your pipeline
- Find teaming partners
- Similar grant opportunities
- Ask GovTribe AI about this opportunity