Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)
Closed Posted
- Opportunity number
- PAR-24-305
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement
- Category
-
- Health
- Eligible applicants
-
- City/Township Governments
- Tribal Governments (Federally Recognized)
- Tribal Organizations (Not Federally Recognized)
- Small Businesses
- Non-501(c)(3) Nonprofits
- Independent School Districts
- For Profit Organizations
- State Governments
- Public or Indian Housing Auth.
- Higher Education Inst. (Private)
- 501(c)(3) Nonprofits
- County Governments
- Higher Education Inst. (Public)
- Other
- Special District Governments
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
This Notice of Funding Opportunity (NOFO) invites U54 cooperative agreement applications for the Centers for Precision Disease Modeling. The goal is to support collaborative research projects that link personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. The aim is to enhance the predictive value of preclinical studies through precision animal models. Each Center will develop a process to nominate human genomic variants for high-throughput testing, conduct functional and phenotyping analyses, and create and distribute precision animal model resources. The funding is provided by the Department of Health and Human Services, National Institutes of Health, under the Research Infrastructure Programs (CFDA 93.351). The opportunity is open to a wide range of applicant types, including higher education institutions, public housing authorities, state/local governments, and non-profit entities.
Recent awards under the Research Infrastructure Programs have ranged from smaller equipment grants around $100,000 to larger multi-year awards exceeding $2 million. The typical award period is 1-5 years, and recipients are frequently major research universities, academic medical centers, and other biomedical research institutions. Places of performance are typically at the recipient institutions' research facilities across the United States.
Synopsis
This Notice of Funding Opportunity (NOFO) invites U54 cooperative agreement applications for the support and advancement of the Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. By functionally linking these areas of research, the Centers aim to enhance the predictive value of preclinical studies through the use of precision animal models. Each Center will develop a process by which the research community can nominate unique human genomic variants for cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will support assays to conduct comprehensive functional and phenotyping analyses to evaluate disease-causing variants. A key mission of the Centers is the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. While the Centers will focus on a limited number of targeted projects, they are expected to develop and maintain multifaceted research activities that can be adjusted to accommodate a wide range of diseases.
Files
| File | Type | Posted |
|---|---|---|
| PAR-24-305-Full-Announcement.html | HTML file |
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