Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- PAR-25-037
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- State Governments
- County Governments
- Higher Education Inst. (Public)
- City/Township Governments
- Non-501(c)(3) Nonprofits
- Small Businesses
- 501(c)(3) Nonprofits
- For Profit Organizations
- Other
- Independent School Districts
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- Special District Governments
- Tribal Organizations (Not Federally Recognized)
- Public or Indian Housing Auth.
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. The grant program, offered by the Department of Health and Human Services National Institutes of Health, seeks hypothesis-generating or hypothesis-testing studies that utilize in vivo, in situ, or in vitro experimental paradigms, including model organisms or human cell-based assays. The resulting data and insights should be disseminated to enrich common data resources in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification.
This R21 funding opportunity is intended for early-stage, high-risk, exploratory approaches or proof-of-concept studies where little or no preliminary data exists. Eligible applicants include nonprofits, for-profits, government entities, and higher education institutions. The grant program is funded under the Mental Health Research Grants (CFDA 93.242) federal grant program, which typically provides awards ranging from smaller exploratory grants around $50,000 to large multi-year projects exceeding $3 million in total costs, with durations spanning 2-5 years.
Synopsis
This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components and processes. The resulting paradigms, component pathways and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R21 activity code) can be used for applications to develop early stage, high-risk, exploratory approaches or establish proof-of-concept where there is little or no preliminary data. Applicants proposing to develop lines of inquiry where feasibility or proof of concept has been established should apply to the companion R01 NOFO (PAR-xx-xxx).
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-037-Full-Announcement.html | HTML file |
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