PAR-25-037-Full-Announcement.html

This document is a Notice of Funding Opportunity (NOFO) for the Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed) grant program. The NOFO is solicitation number PAR-25-037 and is offered by the Department of Health and Human Services National Institutes of Health.

The grant program encourages research on the biology of high confidence risk factors associated with complex brain disorders, focusing on intracellular, transcellular, and circuit substrates of neural function. Studies may utilize in vivo, in situ, or in vitro experimental paradigms, including model organisms or human cell-based assays. The resulting data and insights should be disseminated to enrich common data resources to bridge the gap between disease risk factors, biological mechanisms, and therapeutic target identification. The R21 activity code is intended for early-stage, high-risk, exploratory approaches or proof-of-concept studies where little or no preliminary data exists. Eligible applicant types include nonprofits, for-profits, government entities, and higher education institutions. The grant program is funded under the Mental Health Research Grants (CFDA 93.242) federal grant program.