Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)
Closed Posted
- Opportunity number
- PAR-25-038
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Grant
- Category
-
- Health
- Eligible applicants
-
- For Profit Organizations
- 501(c)(3) Nonprofits
- Tribal Governments (Federally Recognized)
- Higher Education Inst. (Private)
- Public or Indian Housing Auth.
- Independent School Districts
- Higher Education Inst. (Public)
- Special District Governments
- State Governments
- County Governments
- Small Businesses
- Tribal Organizations (Not Federally Recognized)
- Other
- Non-501(c)(3) Nonprofits
- City/Township Governments
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
This Notice of Funding Opportunity (NOFO) from the Department of Health and Human Services National Institutes of Health (NIH) encourages research on the biology of high-confidence risk factors associated with complex brain disorders. The research should focus on the intracellular, transcellular, and circuit substrates of neural function, utilizing in vivo, in situ, or in vitro experimental paradigms. Studies should aim to elucidate the neurobiological impact of individual or combined risk factors, rather than model the disorders themselves, and the resulting data should contribute to common and federated data resources. The R01 mechanism is intended for applications where feasibility or proof-of-concept has been established, while the companion R21 NOFO is for exploratory research at earlier stages.
Eligible applicant types include higher education institutions, non-profits, small businesses, and state/local governments. The funding opportunity is part of the Mental Health Research Grants program (CFDA 93.242), which supports a range of mental health research initiatives. Recent Federal Grant Awards under this program have ranged from smaller exploratory grants around $50,000 to large multi-year projects exceeding $3 million in total costs, with typical award durations spanning 2-5 years. The research activities are generally conducted at the facilities of recipient organizations across the United States.
Synopsis
This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular, and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components, and processes. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R01 activity code) can be used for applications to further develop lines of inquiry where feasibility or proof-of-concept has been established. Applicants proposing exploratory research at the early and conceptual stages of project development should apply to the companion R21 NOFO PAR-24-025
Files
| File | Type | Posted |
|---|---|---|
| PAR-25-038-Full-Announcement.html | HTML file |
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