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This document is a Notice of Funding Opportunity (NOFO) for the Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed) grant program. The program is funded by the Department of Health and Human Services National Institutes of Health (NIH), specifically the National Institute of Mental Health (NIMH).

The NOFO encourages research on the biology of high-confidence risk factors associated with complex brain disorders, focusing on intracellular, transcellular, and circuit substrates of neural function. Studies may utilize in vivo, in situ, or in vitro experimental paradigms and should aim to elucidate the neurobiological impact of individual or combined risk factors, rather than model the disorders themselves. The resulting data should contribute to common and federated data resources. The R01 mechanism is intended for applications where feasibility or proof-of-concept has been established, while the companion R21 NOFO is for exploratory research at earlier stages. Eligible applicant types include higher education institutions, non-profits, small businesses, and state/local governments.