Ub-AML substrate for DUB3 project

SOURCES SOUGHT NOTICE

1. Solicitation Number: 75N95019Q00333

2. Title: Ub-AML substrate for DUB3 project

3. Classification Code: 99

4. NAICS Code: 325413

5. Description:
This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only.

Background: The National Center for Advancing Translational Science (NCATS) Chemical Genomics Center (NCGC) regularly screens its small molecule library collections against different enzymes that are implicated in development of diseases. Prostate and breast cancer progression depends on the expression of nuclear receptors for the hormones androgen (AR) and estrogen (ER), respectively. DUB3 is an enzyme that removes ubiquitin (Ub) moieties from both AR and ER, preventing their proteosomal-mediated degradation. Hence, inhibition of DUB3 is a candidate therapy to decrease AR and ER levels.

Purpose and Objectives: NCGC is looking to screen DUB3 for small molecule inhibitors and needs Ub-AML as a substrate for that assay. The acquisition is to procure Ub-AML substrate for the DUB3 project in NCGC Biology.

Project requirements: Ub-AML (catalog # U-556) manufactured by R & D Systems, 614 McKinely PL NE, Minneapolis, MN 55413-2610.

Quantity: 10mg

Anticipated period of performance: One-time delivery 4 weeks ARO

Requested Response: The intent of this sources sought notice is to define the procurement strategy (e.g. set-aside, sole source, unrestricted) for a solicitation that NCATS intends to post soon. Interested contractors are requested to respond by (1) identifying how their proposed product meets or exceeds each of the seven salient charactistics listed above, by number; and (2) providing product literature, white papers, or capability statements that demonstrate their bona fide ability to supply such an instrument within the time frame described above.
In addition, please state your business size status and whether you are the manufacturer or authorized distributor of the item(s) you propose.

Please note that NCATS is particularly interested in small business sources. If you are a small business, please state the type of small business (small business; HUBZone; service-disabled, veteran-owned; 8(a); veteran-owned; woman-owned; or small disadvantaged businesses) and your size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible.

The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business and any other information that may be helpful in developing or finalizing the acquisition requirements.

The information submitted must be must be in an outline format that addresses each of the elements of the project requirements stated herein. A cover page and an executive summary may be included but is not required.

The response must include the respondents' technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses to this notice must be submitted electronically to the Contract Specialist. Facsimile responses are NOT accepted.

The response must be submitted to Jessica Adams at jessica.adams@nih.gov.

The response must be received on or before August 28, 2019, 11:00am, Eastern Time.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).

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