Technology InteGrator and AcceleratoR (TIGAR)
Open Solicitation Posted
Not the latest version. See the latest special notice from .
- Solicitation number
- ARPA-H-SOL-26-144
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Place of performance
- Washington, District of Columbia, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institutes of Health through ARPA-H seeks innovative biopreservation technologies to unlock temperature-flexible storage for regenerative tissues and organs, with Solution Video submissions for Intake Group 1 due August 12, 2026, and Full Proposals due September 17, 2026 (Amendment 4 extended the original June 8 and August 5 deadlines).
Place of performance is Washington, DC. The TIGAR Exploratory Topic accepts solutions involving new materials, artificial intelligence/machine learning, high-throughput screening, biological interventions, devices, processing methods, analytical technology, and packaging approaches. Proposers must demonstrate functional preservation of either complete structures (organoids, organs, organ sub-units) or one cubic centimeter tissue volumes for 30 days at practical temperatures (-80C, -20C, 4C, or 20-25C room temperature) using conventional equipment, with innovations required to address deployment in thick tissues—cellular-level innovations without tissue deployment strategies are out of scope. Preferred demonstration systems include currently difficult-to-biobank tissues such as organoids, donated tissues, whole organs, organ sub-structures, vascularized allografts, and engineered tissues.
Maximum ARPA-H funding is $2 million USD over 18 months, structured as two 9-month phases with a Phase 1 down-select. Awards are Other Transaction Agreements; only prime/subcontractor teaming is permitted, not multi-party teaming. Eligible proposers include universities, non-profits, small businesses, and commercial entities; FFRDCs and government entities are prohibited as primes unless they possess unique unavailable capabilities with documented justification. All proposers must register in SAM.gov with a valid Unique Entity Identifier.
Evaluation criteria in descending order of importance are Overall Scientific and Technical Merit, Proposer's Capabilities and Related Experience, Contribution to ARPA-H Mission and Relevance to User Experience, and Assessment of Proposed Cost/Price. The NAICS code is 541715. Intake Group 2 has a December 8, 2026 Solution Video deadline and February 5, 2027 Full Proposal deadline, with final ISO closure February 5, 2027 at 11:59 PM ET. Submissions are through the ARPA-H Solution Submission Portal.
Notice text
5 versions
Update #5 · Latest ·
Amendment 4
The ISO was updated to extend the Solution Video submission deadline to August 12, 2026 and the Full Proposal submission deadline to September 17, 2026 for intake Group 1. See page 3 of the full text ISO for more information.
Amendment 3
(1) Appendix B was updated to remove track changes
(2) Appendix C4 was updated to remove an erroneous comment.
Amendment 2
(1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8).
(2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions).
(3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7).
(4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity.
(5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document.
Amendment 1
The ISO was updated with the new webinar and webinar registration dates.
Effort Description:
TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered.
Please ensure to follow this opportunity for any updates.
For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar
For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
Update #4 ·
Amendment 3
(1) Appendix B was updated to remove track changes
(2) Appendix C4 was updated to remove an erroneous comment.
Amendment 2
(1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8).
(2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions).
(3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7).
(4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity.
(5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document.
Amendment 1
The ISO was updated with the new webinar and webinar registration dates.
Effort Description:
TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered.
Please ensure to follow this opportunity for any updates.
For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar
For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
Update #3 ·
Amendment 2
(1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8).
(2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions).
(3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7).
(4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity.
(5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document.
Amendment 1
The ISO was updated with the new webinar and webinar registration dates.
Effort Description:
TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered.
Please ensure to follow this opportunity for any updates.
For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar
For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
Update #2 ·
Amendment 1
The ISO was updated with the new webinar and webinar registration dates.
Effort Description:
TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered.
Please ensure to follow this opportunity for any updates.
For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar
For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
Update #1 ·
Effort Description:
TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered.
Please ensure to follow this opportunity for any updates.
For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar
For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142
Files
Notice history
| Notice | Type | Posted |
|---|---|---|
| Special Notice for Technology InteGrator and AcceleratoR (TIGAR) | Special Notice | |
| This notice | Solicitation |
Similar open opportunities
On GovTribe
Work this opportunity
- Track it in your pipeline
- Find teaming partners
- Similar opportunities
- Ask GovTribe AI about this opportunity