StarDrop Software Renewal

INTRODUCTION
PURSUANT TO FAR Subpart 5.2-Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION.

THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) intends to award a purchase order to intends to negotiate and award a contract to Optibrium Limited for StarDrop Software Renewal. The rationale for this sole source is: NCATS authors program in StarDrop to support structure-based design, fragment-based design, pharmacophore discovery, medicinal chemistry applications, biologics applications, protein and antibody modeling, molecular modeling and simulations, and cheminformatics and QSAR. This software has been in use here at NCATS for the previous two years and is being used in ongoing chemical analysis onsite. In order to provide continuity of science, we must continue to use this database and tools. The software is is solely available through Optibrium Limited.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE
The intended procurement is classified under NAICS code 511210 with a small business size tandard of $38.5 million.

REGULATORY AUTHORITY
The resultant contract will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular (FAC) 2005-101, dated October 26, 2018.

STATUTORY AUTHORITY
This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source.

DESCRIPTION OF REQUIREMENT

Background
The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives.

The National Center for Advancing Translational Sciences (NCATS) is a part of the National Institutes of Health (NIH), which mission it is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions.

The NCATS Chemical Genomics Center (NCGC) is tasked with identifying and developing novel small molecule leads against a wide spectrum of human disease targets, which it accomplishes by screening thousands of small molecules in collaboration with both intra-and extramural researchers. In pursuit of this goal, the Center has a strong internal transdisciplinary team of scientists who continually discover novel small molecules for application against a wide range of human diseases. As such, NCATS is in need of a license for software that allows to quickly identify effective compounds in drug discovery.

Purpose and Objectives
This requisition is to procure Optibrium brand-name only StarDrop software license renewal and installation services.

Project Description
StarDrop license including:

One (1) floating license and one (1) fixed license to StarDrop w/ADME QSAR, P450, A Suto-Modeller, Nova, BIOSTER, torch 3D, SeeSAR and MPO Explorer modules used for analyzing datasets of chemical structures and related biological or toxicity data in compound collections.

Contractor is responsible for delivering a software that fulfills the following requirements:
• Easily guides the user through multiparameter optimization; these include but are not limited to: potency, ADME, and safety;
• Provides ease of use through the following features: card view, probabilistic scoring, glowing molecule, chemical space, R-group analysis, and data visualization;
• Allows for flexible integration between different modules, these include but are not limited to: ADME QSAR, P450 Metabolism, Derek Nexus, Auto-Modeller, torch3D, SeeSAR, MPO Explorer, Nova, and BIOSTER; and
• Provides a one-year base license period with two (2) option periods to extend license period for one-year each.

Period of Performance
Base Period (Contract Year 1): February 1, 2019 through January 31, 2020.
Option Period 1 (Contract Year 2): February 1, 2020 through January 31, 2021.
Option Period 2 (Contract Year 3): February 1, 2021 through January 31, 2022.

CLOSING STATEMENT
This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice.

Respondents that believe that they are manufacturers or authorized resellers of the brand-name product specified in this announcement must provide, as part of their response: (a) product, catalog, model, and/or part number(s); (b) product description; (c) all relevant information and documentation that the item(s) offered meets the salient physical, functional, or performance characteristics as specified in the purchase description; quantity; estimated price or cost; shipping, handling, and/or installation charges; and delivery date after receipt of order.

Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price proposal must include the labor categories, an estimate of the number of hours required for each labor category, fully loaded fixed hourly rate for each labor category, breakdown and rationale for other direct costs or materials, and the total amount.

Responses to this notice must include sufficient information to establish the interested parties' bona fide capabilities of providing the product or service. The price quote shall include: total price, delivery date after receipt of order, and any other information or factors that may be considered in the award decision. Such factors may include: technical capability to perform the services of the requirement, price, and past performance [see FAR 13.106-2(b)(3)].

In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses must be received by 12:00 p.m. Eastern Standard Time, Friday,
December 28, 2018, and reference number 75N95019Q00036. Responses must be submitted electronically to Mark McNally, Contract Specialist, at mark.mcnally@nih.gov. Fax responses will not be accepted.

Contracting Office Address:
NCATS Section
NIDA Office of Acquisition, NIH
6001 Executive Blvd
Room 3287, MSC 9534
Bethesda, MD 20892-9534

All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.

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