RRPV Solicitation Summary: Agnostic Diagnostics

The Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response (ASPR) has issued a Special Notice regarding a Request for Project Proposals (RPP) for "Agnostic Diagnostics" through the Rapid Response Partnership Vehicle (RRPV) Consortium. This solicitation was posted on October 23, 2025, with a proposal due date of November 20, 2025. The opportunity is being administered by the Biomedical Advanced Research and Development Authority (BARDA) and seeks to advance diagnostic capabilities for pathogen detection. Interested parties can access the full RPP details and consortium membership information through the RRPV website at www.rrpv.org. This is an open competition with no set-aside restrictions for small businesses or other designated groups.

BARDA is seeking support for advanced development, clinical evaluation, and FDA clearance of metagenomic next-generation sequencing (mNGS)-based diagnostic assays capable of detecting viral and bacterial pathogens in clinical specimens such as respiratory samples. The agency requires contractors to utilize either existing mNGS sequencing platforms or platforms currently in development, with solutions sought for both laboratory and point-of-care settings. A critical requirement is that proposed systems must be highly flexible and rapidly adaptable, capable of reconfiguring through database or software updates to identify emerging pathogens during public health emergencies. Contractors must be prepared to demonstrate capability in advanced development, clinical evaluation workflows, and FDA regulatory clearance pathways. Proposals are due by November 20, 2025, and interested contractors should review the complete RPP documentation available through the RRPV Consortium website to understand all technical and administrative requirements.