Research Study; Mapping Temporal Dynamics of Immune responses in Severe Multisystem and Orthopedic Polytrauma Using single-Cell Multiomics

The Defense Health Agency is seeking a research study focused on mapping temporal dynamics of immune responses in severe multisystem and orthopedic polytrauma using single-cell multiomics technologies. The project aims to advance understanding of polytrauma inflammatory syndrome by characterizing early circulating immune responses through advanced proteomic and transcriptomic analysis. Interested parties must submit a detailed capability statement electronically by 12:00 pm Eastern on April 29, 2025, to Brandon Clingan. The capability statement must not exceed 10 pages and should include company information, contact details, Unique Entity ID, CAGE Code, current government contract vehicles, relevant experience, and capabilities matching the research requirement. Companies must be registered in the System for Award Management (SAM) and fall under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences.

This pre-solicitation notice is not a set-aside contract and does not guarantee a future award. The research study involves experimental development services for national defense, specifically targeting single-cell multiomics analysis of immune responses. Specific research objectives include determining circulating immune cell profile signatures using CyTOF and identifying enriched signaling pathways for outcome prediction using scRNA-seq. While no specific award value is mentioned, the contract falls under the Product Service Code AC13 for National Defense R&D Services. The potential research timeline and specific quantitative requirements are not explicitly detailed in the pre-solicitation notice, which is primarily designed to gather information and assess potential contractor capabilities for this specialized medical research project.