Research and development (R&D) that will contribute toward Advanced Research Projects Agency for Health (ARPA-H) mission needs and Small Business Innovation Research (SBIR) program objectives.

Closed Solicitation Posted

Not the latest version. See the latest solicitation from .

Solicitation number
75N91024R00006
Agency
Responses due
Set-aside
Total Small Business

Opportunity facts

Place of performance
United States

Notice details come from SAM.gov. Updated .

About this opportunity

This solicitation seeks research and development proposals in six areas that will contribute to the mission of the Advanced Research Projects Agency for Health and objectives of the Small Business Innovation Research program. The soliciting agency is the Department of Health and Human Services National Institutes of Health National Cancer Institute. Proposals are due by February 22, 2024 and must address one of the following topics: inexpensive plant-based manufacturing of viral vectors for gene therapies; a LymphoLab ProDiscover Kit; continuous monitoring of vascular health using smart biomimetic implantables; a personalized medicine platform for predicting response to immunotherapy; fully autonomous neonatal echocardiography for diagnosis of critical congenital heart disease; or improving identity and access management with clinical context. Questions are due by February 15, 2024.

The set-aside designation is for total small business. The NAICS code is 541715 and PSC code is R420. There is no mention of incumbent contractors. Awards are anticipated to be issued by the end of September 2024 for research and development to be conducted in the United States. Proposals must follow the prescribed technical and business proposal templates and are subject to evaluation based on the criteria provided therein, including technical merit, qualifications, and commercial potential.

Notice text

5 versions

Update #5 · Latest ·

Amendment 5 is hereby issued to provide Answers to solicitation questions received by the due date and time for receipt of questions.  All Amendments are provided in the Attachments section of this solicitation.

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Amendment 4 is hereby issued to provide Answers to solicitation questions received by the due date and time for receipt of questions. 

In addition, due to a small typographical error identified in Objectives section of the Appendix A Phase I Technical Proposal, this attachment has been updated, and the corrected file attachment has been added to replace to original.  See Q&A for Amendment 4 for further information. All Amendments are provided in the Attachments section of this solicitation.

One more Amendment will be issued over the next few days to provide answers to all remaining questions. 

*****************************************************************************

Amendment 3 is hereby provided to extend the Due Date for the submission of proposals to February 29, 2024, 5:00PM ET.

All amendments are attached to this posting. Please scroll down to the bottom of the page to see the attachments of all amendments as well as all the original solicitation documents.  The Government is working to compile and finalize the answers to all questions received prior to the due date and time for solicitation questions, and another Amendment is forthcoming to provide answers to all the remainder of the questions.

************************************************************************************

Amendments 1 and 2 were posted under a separate posting in SAM.gov.  However, due to the difficulty of interested vendors in locating these amendments postings in SAM.gov, the Amendments have been attached here as well. 

***************************************************************************************

SOLICITATION

The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation.  Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.  This solicitation invites proposals in the following areas:  

  • ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies
  • ARPA-H 02 - LymphoLab ProDiscover Kit 
  • ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables 
  • ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy 
  • ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease 
  • ARPA-H 06 - Improving Identity and Access Management with Clinical Context 

Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).

Update #4 ·

Amendment 4 is hereby issued to provide Answers to solicitation questions received by the due date and time for receipt of questions. 

In addition, due to a small typographical error identified in Objectives section of the Appendix A Phase I Technical Proposal, this attachment has been updated, and the corrected file attachment has been added to replace to original.  See F&A for Amendment 4 for further information. All Amendments are provided in the Attachments section of this solicitation.

One more Amendment will be issued over the next few days to provide answers to all remaining questions. 

*****************************************************************************

Amendment 3 is hereby provided to extend the Due Date for the submission of proposals to February 29, 2024, 5:00PM ET.

All amendments are attached to this posting. Please scroll down to the bottom of the page to see the attachments of all amendments as well as all the original solicitation documents.  The Government is working to compile and finalize the answers to all questions received prior to the due date and time for solicitation questions, and another Amendment is forthcoming to provide answers to all the remainder of the questions.

************************************************************************************

Amendments 1 and 2 were posted under a separate posting in SAM.gov.  However, due to the difficulty of interested vendors in locating these amendments postings in SAM.gov, the Amendments have been attached here as well. 

***************************************************************************************

SOLICITATION

The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation.  Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.  This solicitation invites proposals in the following areas:  

  • ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies
  • ARPA-H 02 - LymphoLab ProDiscover Kit 
  • ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables 
  • ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy 
  • ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease 
  • ARPA-H 06 - Improving Identity and Access Management with Clinical Context 

Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).

Update #3 ·

Amendment 3 is hereby provided to extend the Due Date for the submission of proposals to February 29, 2024, 5:00PM ET.

All amendments are attached to this posting. Please scroll down to the bottom of the page to see the attachments of all amendments as well as all the original solicitation documents.  The Government is working to compile and finalize the answers to all questions received prior to the due date and time for solicitation questions, and another Amendment is forthcoming to provide answers to all the remainder of the questions.

************************************************************************************

Amendments 1 and 2 were posted under a separate posting in SAM.gov.  However, due to the difficulty of interested vendors in locating these amendments postings in SAM.gov, the Amendments have been attached here as well. 

***************************************************************************************

SOLICITATION

The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation.  Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.  This solicitation invites proposals in the following areas:  

  • ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies
  • ARPA-H 02 - LymphoLab ProDiscover Kit 
  • ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables 
  • ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy 
  • ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease 
  • ARPA-H 06 - Improving Identity and Access Management with Clinical Context 

Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).

Update #2 ·

Amendments 1 and 2 were posted under a separate posting in SAM.gov.  However, due to the difficulty of interested vendors in locating these amendments postings in SAM.gov, the Amendments have been attached here as well. 

**********************************

The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation.  Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.  This solicitation invites proposals in the following areas:  

  • ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies
  • ARPA-H 02 - LymphoLab ProDiscover Kit 
  • ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables 
  • ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy 
  • ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease 
  • ARPA-H 06 - Improving Identity and Access Management with Clinical Context 

Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).

Deadline for Receipt: Proposals must be received by February 22, 2024, 5:00 PM EDT.

Update #1 ·

The Advanced Research Projects Agency for Health (ARPA-H) invites small business concerns (SBCs) to submit research proposals under this Small Business Innovation Research (SBIR) Contract Solicitation.  Firms with the capability to conduct research and development (R&D) and to commercialize the results of that R&D, are encouraged to participate.  This solicitation invites proposals in the following areas:  

  • ARPA-H 01 - Inexpensive plant-based manufacturing of viral vectors for gene therapies
  • ARPA-H 02 - LymphoLab ProDiscover Kit 
  • ARPA-H 03 - Continuous Monitoring of Vascular health using Smart Biomimetic Implantables 
  • ARPA-H 04 - Personalized medicine platform for predicting response to immunotherapy 
  • ARPA-H 05 - Saving Baby Hearts: Fully Autonomous Neonatal Echocardiography for the Diagnosis of Critical Congenital Heart Disease 
  • ARPA-H 06 - Improving Identity and Access Management with Clinical Context 

Deadline for Questions: Solicitation questions must be received by February 15, 2024, 5:00 PM EDT. Please send questions to the ARPA-H SBIR/STTR Program mailbox (sbir@arpa-h.gov).

Deadline for Receipt: Proposals must be received by February 22, 2024, 5:00 PM EDT.

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