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This document is a solicitation amendment extending the proposal deadline for a Small Business Innovation Research (SBIR) contract opportunity with the Advanced Research Projects Agency for Health (ARPA-H). The amendment provides more time for offerors to submit proposals due to the volume of questions received. The deadline for proposal receipt is extended to February 29, 2024 at 5:00 PM EDT. ARPA-H is seeking research and development proposals in six areas: inexpensive plant-based manufacturing of viral vectors for gene therapies; a LymphoLab ProDiscover Kit; continuous monitoring of vascular health using smart biomimetic implantables; a personalized medicine platform for predicting response to immunotherapy; fully autonomous neonatal echocardiography for the diagnosis of critical congenital heart disease; and improving identity and access management with clinical context. The Department of Health and Human Services National Institutes of Health National Cancer Institute is the issuing agency. Offerors must acknowledge each amendment by including a signed Standard Form 30 with their proposal.

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75N91024R00006 x x

1 copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted ; or (c) By separate letter or electronic communication which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE

RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR

OFFER. If by virtue of this amendment you desire to change an offer already submitted , such change may be made by letter or electronic communication, provided each letter or electronic communication makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

x

NCI-EXEC

Bethesda, MD 20892-7511 National Cancer Institute National Institutes of Health

13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

12. ACCOUNTING AND APPROPRIATION DATA (If required) is not extended.is extended, Items 8 and 15, and returning

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended , by one of the following methods: (a) By completing

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

FACILITY CODE CODE

10B. DATED (SEE ITEM 13)

10A. MODIFICATION OF CONTRACT/ORDER NO.

9B. DATED (SEE ITEM 11)

9A. AMENDMENT OF SOLICITATION NO.

CODE

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

7. ADMINISTERED BY (If other than Item 6)CODE 6. ISSUED BY

PAGE OF PAGES

4. REQUISITION/PURCHASE REQ. NO.3. EFFECTIVE DATE2. AMENDMENT/MODIFICATION NO. 5. PROJECT NO. (If applicable)

1. CONTRACT ID CODE

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

CHECK ONE A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority) appropriation data, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

E. IMPORTANT: Contractor is not is required to sign this document and return ___1_______________ copies to the issuing office.

ORDER NO. IN ITEM 10A.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

THE PURPOSE OF THIS AMENDMENT IS TO EXTEND THE PROPOSAL DUE DATE TO FEBRUARY 29, 2024, 5:00

PM ET.

This extension is being provided due to the volume of questions received from potential offerors as the Government is still compiling answers to all questions that were received by the due date and time of February 15, 2024, 5:00PM ET. Therefore, another amendment following this will be forthcoming providing answers to all remaining questions.

Offerors are required to acknowledge EACH Solicitation Amendment by including EACH Standard

Form 30 (SF-30) signed by your organization's signature authority and are required to be submitted with your proposal.

Continued ...

16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)15A. NAME AND TITLE OF SIGNER (Type or print)

15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 15B. CONTRACTOR/OFFEROR 16C. DATE SIGNED

(Signature of person authorized to sign) (Signature of Contracting Officer)

MANDIE S. WHITE

STANDARD FORM 30 (REV. 11/2016)

Prescribed by GSA FAR (48 CFR) 53.243

Previous edition unusable

Except as provided herein, all terms and conditions of the document referenced in Item 9 A or 10A, as heretofore changed, remains unchanged and in full force and effect .

To all potential offerors

02/21/2024 x

ITEM NO. SUPPLIES/SERVICES QUANTITY UNIT UNIT PRICE AMOUNT

NAME OF OFFEROR OR CONTRACTOR

2 2

CONTINUATION SHEET

REFERENCE NO. OF DOCUMENT BEING CONTINUED PAGE OF

(A) (B) (C) (D) (E) (F)

75N91024R00006

The period for receipt of solicitation questions has ended.

PROPOSAL DUE DATE: FEBRUARY 29, 2024, 5:00PM EDT

(CHANGED)

NSN 7540-01-152-8067 OPTIONAL FORM 336 (4-86)

Sponsored by GSA

FAR (48 CFR) 53.110

Text1:
Date2_af_date:
Date3_af_date: 2/21/24
2024-02-21T10:51:47-0500
Mandie S. White -S

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