Registration, Storage and Distribution of Chemicals and Drugs for Pre-Clinical Discovery Evaluation and Development

Amendment 0001 - To make a correction to the Mandatory Qualification Criteria for Facility Mandatory Qualification, see attachment. 

Please see attachments (Pre-Solicitation Notice and Statment of Work) for complete description.

The Drug Synthesis and Chemistry Branch (DSCB) of the Developmental Therapeutics
Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the Natio  al Cancer 
Institute (NCI) is seeking support services to operate and maintain the National Cancer Institute’s 
Chemotherapeutic Agents Repository (NCI-CAR).  This acquisition is responsible for providing an 
informational interface with NCI and external investigators that are submitting or requesting 
research compounds; for updating of the chemical database which includes chemical, inventory, 
receiving and shipping information; systematic file and record keeping of both current and archival 
information related to repository activities; and reacquisition of samples for continued chemical 
and biological studies.  Towards this goal, the Program acquires and evaluates about 5,000 single 
agents each year in anticancer assays.  In addition, research samples are provided to the general 
research community both in vialed and plated format.  NCI-CAR is responsible for receiving, storage 
and distribution services along with curating an inventory of approximately 500,000 - 600,000 
individual samples and associated chemical, inventory and distribution data.  Approximately 400 
samples are received monthly, registered, and shipped to NCI testing facilities; an additional 
2,500 samples are weighed inventory and shipped to research investigators both in the U.S. (including NCI)
and foreign countries.