Preclinical Pharmacokinetic and Pharmacology Evaluations of

The purpose of this Small Business Sources Sought Notice is to identify qualified small business concerns including HUBZone small businesses; service disabled, veteran-owned small businesses; 8(a) small businesses; women-owned small businesses; or small disadvantaged businesses that are interested in and capable of performing the work described herein.  The NCI does not intend to award a contract on the basis of responses received nor otherwise pay for the preparation of any information received.

As a result of this SBSS notice, the NCI may issue a Request for Proposal (RFP).  THERE IS NO SOLICITATION AVAILABLE AT THIS TIME.  However, should such a requirement materialize, no basis for claim against the NCI shall arise as a result of a response to this Small Business Sources Sought Notice or the NCI’s use of such information as either part of our evaluation process or in developing specification for any subsequent requirement.

NCI is seeking services for implementation of bioanalytical methods and conduct of pharmacokinetic evaluations in animals with compounds of interest to the NCI Experimental Therapeutics (NExT) program.  Analysis of samples provided by the NCI from other sources, including human clinical trials, may be requested. Please reference the attached, draft Statement of Work (SOW) for specifics.

The purpose of this acquisition is to obtain analytical, pharmacokinetic, metabolism, pharmacodynamic, and other pharmacologic data on new agents (including small molecules, peptides, oligonucleotides, and other biologicals) for the treatment of cancer. Awardees will implement and validate appropriate established analytical methodologies to quantify compounds in biological fluids and tissues from multiple species and rapid pharmacokinetic assessments to the NCI.  Data generated will be used in all phases of the drug development process, from lead selection and development to the support of early clinical trials. For those agents that are selected for clinical trial, the reports generated under these contracts will comprise a portion of the Investigational New Drug (IND) submission to the Food and Drug Administration (FDA).