OpenEye Software Annual Licenses

The National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, seeks reinstatement of OpenEye Non-Profit Package annual software licenses, with quotes due June 5, 2026 at 2:30 PM EST and award anticipated on or after June 9, 2026. The procurement is a small business set-aside; one source indicates women-owned small business (WOSB), while another indicates general small business.

Place of performance is North Bethesda, Maryland. The OpenEye Non-Profit Package comprises 15 integrated tools: BROOD, EON, FILTER, OEChem TK, OEDocking, OMEGA, OMEGA DB, pKa Prospector, QUACPAC, ROCS, SITEHOPPER, SPRUCE, SZMAP, SZYBKI, and VIDA. The requirement supports molecular modeling, virtual screening, structure-activity relationship analysis, molecular docking, conformer generation, and qHTS data mining conducted by the Early Translation Branch, Chemical Genomics Branch, Informatics Core, and collaborating NCATS researchers. The vendor must maintain compatibility with existing NCATS workflows and internally developed tools, provide licensing updates and support, and ensure continuity with minimal disruption following any coverage lapse.

The solicitation covers three line items: the annual OpenEye Non-Profit Package subscription, a FastROCS annual evaluation license, and a Shape annual evaluation license. The base period runs one year from June 15, 2026 through June 14, 2027, commencing within thirty days of award. NAICS code is 541511 (Custom Computer Programming Services) with a $134 size standard; PSC code is 7A21 (IT and Telecom-Business Application Software). Award will be made using Lowest Priced Technically Acceptable (LPTA) evaluation. Payment is monthly in arrears through the Invoice Processing Platform upon contracting officer representative approval. The contracting officer is Damian A. Hurge; quotes should be submitted to Damian.Hurge@hhs.gov.