Notice of Intent to Sole Source - ChromoLogic
Closed Solicitation Posted
- Solicitation number
- HCCCC-2025-00493
- Agency
-
CDC Office of Acquisition Services
Centers for Disease Control and Prevention, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541990 All Other Professional, Scientific, and Technical Services
- PSC
- AJ12 General Science And Technology R&D Services; General Science And Technology; Applied Research
- Place of performance
- California 91016, United States
- Points of contact
Notice details come from SAM.gov. Updated .
About this opportunity
The Department of Health and Human Services Centers for Disease Control and Prevention (CDC) is seeking to sole-source a contract with ChromoLogic for specialized scientific research services related to pulmonary fibrosis detection. The primary objective is to collaborate with ChromoLogic to evaluate existing test samples from rats exposed to silica-containing engineered stone dusts, with a focus on developing predictive algorithms for pre-symptomatic pulmonary fibrosis. The vendor will be required to perform comprehensive miRNA analysis, including plasma sample evaluation, miRNA extraction, sequencing, and bioinformatic analysis using proprietary algorithms. Evaluation criteria will center on the vendor's ability to test the usefulness of existing predictive models for radiation-induced pulmonary fibrosis in detecting silica-induced fibrosis. The solicitation was posted on December 30, 2024, with a response deadline of January 8, 2025, indicating a relatively short procurement timeline.
The contract opportunity does not have a specific set-aside designation and is classified under NAICS category 541990 for Other Professional, Scientific, and Technical Services. ChromoLogic is the sole identified potential contractor, with the place of performance located in Monrovia, California. The procurement appears to be under $250,000, based on the attached justification document, and will leverage ChromoLogic's unique capabilities in next-generation sequencing and miRNA biomarker identification. The research will involve analyzing plasma samples to evaluate circulating miRNA expressions and develop computational predictive models for pre-symptomatic fibrosis detection. The contract is currently approved through November 27, 2024, suggesting a potential one-year service period with the possibility of future extensions or follow-on research initiatives.
Notice text
Collaboration with vendor is needed to evaluate our existing test samples from rats exposed to silica-containing, engineered stone dusts. Predictive algorithms are needed for pre-sympomatic pulmonary fibrosis, and we will need to be able to partner with the vendor to test whether existing predictive models for pre-symptomatic radiation-induced pulmonary fibrosis are useful for silica-induced fibrosis by using their proprietary algorithms. Samples that will be shipped to the vendor. The vendor will need to be able to evaluate them according to a well-established workflow for miRNA analysis and bioinformatic analysis.They will evaluate plasma sample acceptability and perform miRNA extraction, sequencing, and analysis. They will then evaluate the results obtained to determine comparability to existing circulating miRNA-based fibrosis signatures using proprietary algorithms based on bioinformatic analyses using both Gene Ontology (GO) and Kyoto Encycolpdeia of Genes and Genomes (KEGG) evaluations that have been integrated into a computational, predictive model of pre-symptomatic radiation-induced fibrosis that uses the relative expression of miRNA found in extracellular vescicles of circulating plasmsa in exposed animals. They will use their proprietary predictive model of pre-symptomatic radiation-induced pulmonary fibrosis to determine how useful it is in detecting pre-symptomatic silica-induced pulmonary fibrosis by evaluating the positive predictive value among those samples tested.
Files
| File | Type | Posted |
|---|---|---|
| A13.1. SSJ - 00493- Redacted.pdf |
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