Mouse PK/PD Study Services for NNMT Inhibitors

The National Institutes of Health, Office of the Director, Office of Acquisitions, seeks mouse pharmacokinetic/pharmacodynamic study services for NNMT inhibitors on a firm-fixed-price basis, with responses due August 24, 2026 at 8:00 AM EST. This is an unrestricted, competitive acquisition under FAR 12.603 (streamlined solicitation for commercial products/services) not expected to exceed the simplified acquisition threshold.

Place of performance is not specified. The contractor must perform single-dose oral and intravenous studies in mice using ten NNMT inhibitor test articles supplied by NCATS—eight for parent compound monitoring only and two for parent compound and 1-methylnicotinamide monitoring—with a sample size of three mice per time point. The period of performance is up to three months from receipt of the purchase order, with final report delivery within three weeks of study completion. The contractor must provide all personnel, materials, equipment, laboratory resources, and supplies using established standard operating procedures and fit-for-purpose bioanalytical methods.

Key deliverables include plasma concentration data, concentration-versus-time tables and curves, calculated pharmacokinetic parameters, and a final study report in Excel and/or PDF format. All generated data is considered confidential government property and cannot be published without prior written permission. The NAICS code is 541715 (Research and Development in Physical, Engineering, and Life Sciences), with a small business size standard of 1,000 employees. Award will be made to the responsible offeror whose proposal represents best value, considering price, technical capability, past performance, and delivery schedule. Responses must include unit and total price, shipping and handling costs, delivery timeframe, F.O.B. point, product/service description, UEI, TIN, and business size certification. Offerors must be actively registered in SAM. Submit responses electronically to Jaddua.Johnston@nih.gov; contact contracting specialist at 240-569-0006.