Human/Primate Hi-resolution Upright PET scanner

This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement.

This notice is issued to help determine the availability of qualified companies under the NAICS Code 334516 - Analytical Laboratory Instrument Manufacturing, technically capable of meeting the Government requirement, to determine the method of acquisition, and availability of domestic sources manufactured in the United States in sufficient and reasonably available commercial quantities and of a satisfactory quality. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice.

The Government will NOT be responsible for any costs incurred by the respondents to this notice. This notice is strictly for research and information purposes only. Small businesses are encouraged to respond.

For equipment/supply requirements, responses must include the place of manufacturing (i.e. address if supply/equipment is a domestic end product and include country of manufacture). For equipment/supply requirements, small businesses must also address the size status of the manufacturer under the applicable NAICS code (i.e. address Non-Manufacturer Rule).

Statement of Need and Purpose:

The NIDA IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit has a requirement to procure a human/primate PET scanner (piPET Hi-Res Human/Primate) with the capacity to provide pre-clinical scanner images of large primates (e.g. rhesus macaques) and humans without blocking vision, in a sitting position, and with a small physical footprint. The imaging system must be tabletop, light-weight, and easily transported. The selected scanner shall be able to deliver PET imaging performance with a minimum 1.5 mm reconstructed resolution and high sensitivity.

Background Information and Objective: 

The goal of the Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit is to better understand the neurobiological antecedents of illicit drug use and abuse, the neuronal consequences of short and long-term drug use and the potential reversibility of these neuroadaptations. The major paradigm employed towards this goal is the development and application of novel neuroimaging tools, predominantly PET applied together with behavioral, and pharmacological manipulations and genetic investigations in preclinical protocols. The long-term objective of this research is to inform the development of better behavioral and pharmacological interventions to treat substance abuse and help prevent vulnerable individuals from initiating drug use.

Purchase Description: NIDA requires the following Brand-name or Equal Primate PET scanner.

piPET® PRIMAVERA, Positron Emission Tomography (PET) scanner for preclinical research. Upgrade piPET® with an Ultra-High Resolution Detector.

           

Qty.

Model #

Description

1

N/A

Upgrade piPET® with an Ultra-High Resolution Detector

• PET Detector Ring comprising 16 gamma ray detectors. Each gamma ray detector contains 3,468 lutetium-based scintillating crystal elements (1.5mm x 1.5mm x 10mm) read out by PS PMTs.
• Updated Rotating Calibration/Transmission source mechanism (compatible 0.5mCi Ge-68 line source PET-220/1 must be acquired separately from Sanders Medical Products)

1

BBI-piPET-Upright-Human

Upright vertical mount system integrated with a human patient chair for behavioral experiments

Salient characteristics:

NIDA requires a Brand-name or Equal Primate PET scanner with the following salient characteristics.

πPET® Ultra-High Resolution Detector (UHR) Upgrade Technical Specifications

Parameter

πPET® Detector

(currently installaed)

πPET® Detector

(PROPOSED UPGRADE)

Detector material / Element size

LYSO  / 2x2x13 mm3

LYSO / 1.5x1.5x10 mm3

Number of detector elements

15,210

55,488

Photo detector

Photomultiplier (PMT)

Photomultiplier (PMT)

Trigger

Dual Threshold

Dual Threshold

Field-of-View (FOV) diameter

220 mm

250 mm

Detector Axial FOV extent

85 mm

173 mm

Standard Mounting

Tabletop

Tabletop

Mounting Option 1 (Primate, Sitting)

Awake™ vertical mount system integrated with a primate chair for behavioral experiments

Awake™ vertical mount system integrated with a primate chair for behavioral experiments

Mounting Option 2 (Human, Sitting)

-

Upright vertical mount system integrated with a human patient chair for behavioral experiments

Mounting Option 3 (Human, Supine)

-

Patient bed integrated with a device cart

Reconstruction

- Filtered Backprojection (FBP),

- BrainBio Iterative 3D Maximum-Likelihood Estimation Method (3D MLEM)

- Filtered Backprojection (FBP),

- BrainBio Iterative 3D Maximum-Likelihood Estimation Method (3D MLEM)

Data format

List-mode

List-mode

Attenuation correction

Options:

- Transmission scan-based

- Co-registered CT

Options:

- Transmission scan-based

- Co-registered CT

Axial spatial resolution

2.0 mm

1.5 mm

Transverse axial resolution

2.1 mm (FOV center)

1.6 mm (FOV center)

Timing resolution and gate

1 ns / 4 ns

1 ns / 4 ns

Transmission scan

Line source, Germanium-68

(ordered separately)

Line source, Germanium-68

(ordered separately)

Quality assurance sources

Cylinder Source, Germanium-68

(ordered separately)

Cylinder Source, Germanium-68

(ordered separately)

PET image format

DICOM

DICOM

Quantity: One (1) PET scanner, to include data acquisition electronics, computer, and processing/image reconstruction software. Included full installation, user training, one (1) year warranty and maintenance service including parts and labor, and warranty will be extended for the duration of any system repairs or replacement.

Delivery Date:  Delivery shall be between 52 weeks after receipt of order.

Period of Performance: Production to begin immediately upon contract award and delivery should be within 52 weeks of contract award. Full one-year warranty to begin upon installation. Warranty and maintenance service including parts and labor. Warranty will be extended for the duration of any system repairs or replacement. This requirement may include options to extend the period of performance and or options for increased quantity.

Capability Statement /Information Sought:

Companies that believe they possess the capabilities to provide the required products or services should submit documentation of their ability to meet each of the project requirements to the Contracting Officer. The capability statement must specifically address each of the project requirements separately.  Additionally, the capability statement should include 1) the total number of employees, 2) the professional qualifications of personnel as it relates to the requirements outlined, 3) any contractor GSA Schedule contracts and/or other government-wide acquisition contracts (GWACs) by which all of the requirements may be met, if applicable, and 4) any other information considered relevant to this program. Capability statements must also include the Company Name, Unique Entity ID from SAM.gov, Physical Address, and Point of Contact Information. The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

Interested companies are required to identify their type of business, applicable North American Industry Classification System (NAICS) Code, and size standards in accordance with the Small Business Administration. The government requests that no proprietary or confidential business data be submitted in a response to this notice. However, responses that indicate the information therein is proprietary will be properly safeguarded for Government use only. Capability statements must include the name and telephone number of a point of contact having authority and knowledge to discuss responses with Government representatives. Capability statements in response to this market survey that do not provide sufficient information for evaluation will be considered non-responsive. When submitting this information, please reference the solicitation notice number.

Submission Instructions:

The response is limited to ten (10) page limit.  The 10-page limit does not include the cover page, executive summary, or references, if requested.

All responses to this notice must be submitted electronically to the Contracting Officer Identified below. The response must be received on or before July 18, 2023, at 3:00 pm EST. Facsimile responses are NOT accepted.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in www.sam.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”

Closing Statement: THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95023Q00436. Responses must be submitted electronically to Llakim Dubroff, Contract Specialist, at Llakim.Dubroff@nih.gov U.S. Mail and Fax responses will not be accepted.

Primary Point of Contact:

Llakim Dubroff, Contract Specialist