HT942525P0045 Notice of Intent to Sole Source
Closed Special Notice Posted
- Solicitation number
- HT942525P0045
- Agency
-
Defense Health Agency
Department of Defense
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 325413 In-Vitro Diagnostic Substance Manufacturing
- Place of performance
- Frederick, Maryland 21702, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The Defense Health Agency Contracting Activity (DHACA) has issued a Notice of Intent to Sole Source contract modification (HT942525P0045) to Aptagen, LLC, located in Jacobus, Pennsylvania. This special notice, posted on December 17, 2025, announces the agency's intention to expand an existing contract on a sole source basis in accordance with Federal Acquisition Regulation Part 6. The modification will increase service delivery from the incumbent contractor, who has been identified as the only responsible source capable of meeting the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) requirements. The contract modification does not substantively alter the Performance Work Statement except for adjustments to the scope of DNA aptamer generations and the addition of pseudovirus targets. This special notice is relevant to contractors in the in-vitro diagnostic substance manufacturing and health research and development services sectors.
The primary objective of this contract modification is to support USAMRIID's project CB11484, which focuses on the development of broad-spectrum DNA aptamers capable of neutralizing toxins and viruses. USAMRIID requires between one and four DNA Aptamer Library Generation cycles annually, with each library containing approximately 1,000 to 10,000 targeted aptamers designed to interact with specific pseudoviruses, alpha-conotoxins, and palytoxins across four to six viral targets. The contract specifies that services will be performed in Frederick, Maryland. The interested parties must submit observations or comments regarding this sole source justification by January 6, 2026. While this notice does not establish traditional eligibility criteria for new competitors, it indicates that Aptagen, LLC has been determined to possess unique technical capabilities in this embryonic and specialized field of DNA aptamer development that has not previously been employed at USAMRIID.
Notice text
The Defense Health Agency Contracting Activity (DHACA) intends to modify the existing contract for an increase in service on a sole source basis In Accordance With (IAW) Federal Acquisition Regulation (FAR) part 6 to Aptagen, LLC located at 250 N Main Street, Jacobus, PA 17407 as the only responsible source that can provide the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) for services. The Performance Work Statement has not changed other than to adjust the number of DNA aptamer generations being provided and adding an additional target of pseudoviruses. USAMRIID has a need to generate no less than one (1) but not to exceed four (4) DNA Aptamer Library Generation per year.
These aptamer libraries will consist of ~1000 - ~10,000 targeted aptamers. These libraries target specific pseudoviruses and/or alpha-conotoxins and/or palytoxins and should be capable of broad-spectrum interactions and libraries targeting four (4) to six (6) viral targets. This is a requirement that was originally identified to support USAMRIID’s project CB11484, Development of broad-spectrum DNA aptamers to neutralize toxins. The requirement is crucial as it enables USAMRIID’s researchers to ultimately generate one (1) or more DNA aptamers capable of effectively binding and neutralizing specific toxins and viruses. This is an embryonic methodology with promising outlook for future use in the research field as this and similar strategies have not been employed at the institute previously. The services will performed in Frederick , Maryland 21702.
Notice history
| Notice | Type | Posted |
|---|---|---|
| This notice | Special Notice | |
| Aptamer Library Generation Services for USAMRIID | Award Notice | |
| Notice of Intent to Sole Source - Aptamer Library Generation Services for USAMRIID | Special Notice |
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