Histopathology and antibody screening of Hutchinson Gilford progeria syndrome mouse model DNA editing therapeutic preclinical trial samples.
Closed Pre-Solicitation Posted
- Solicitation number
- 75N98026Q00764
- Agency
-
Office of Logisitics and Acquisition Operations
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541990 All Other Professional, Scientific, and Technical Services
- PSC
- R499 Support- Professional: Other
- Place of performance
- Bethesda, Maryland 20892, United States
- Points of contact
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institutes of Health Office of Logistics and Acquisition Operations intends to solicit histopathology and antibody screening services supporting a preclinical DNA editing therapeutic trial for Hutchinson Gilford Progeria Syndrome, with response due July 20, 2026.
The work involves GLP-compliant pathology services on tissues from 60 HGPS mice across five dose groups treated with vehicle control or SamPro-2, a DNA base editor. The contractor will receive fixed organs following necropsy (scheduled August 14–28, 2026) and perform paraffin embedding, microtomy, and staining of approximately 8,460 total slides across 24 tissue types. Staining requirements include hematoxylin and eosin on all tissues, Movat's pentachrome on ascending and descending aorta, and Picrosirius red and Alizarin red on heart tissue. The contractor must also provide unstained slides to NIH for immunofluorescence histochemistry evaluation and perform FDA-qualified AAV9 antibody screening on 60 mouse serum samples. All work is performed to GLP-compliant standards with comprehensive documentation and final reports. Performance period runs July 30, 2026 through December 31, 2026. All histopathology slides and tissue samples must be returned to NHGRI's Molecular Genetics section upon project completion. Place of performance is not specified in the pre-solicitation notice. No set-aside is anticipated. NAICS 541990; PSC R499.
Notice text
See attached
Files
| File | Type | Posted |
|---|---|---|
| Requirements rev 5.pdf |
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