EXO-NET Pan-Exosome Capture Beads

Description:

This is a Sources Sought notice for domestically manufactured products only. This is NOT a solicitation for proposals, proposal abstracts, or quotations. Per the Buy American Act and Executive Order 14005, the National Institutes of Allergy & Infectious Disease (NIAID) is seeking information for domestically manufactured products only, Per the requirements under the Buy American Act and requirements relating to Executive Order 14005 entitled: “Ensuring the Future is Made in All of America by All of America’s Workers”, in the event that a nonavailability waiver request submitted through the Made in America Office (MIAO)’s Digital Waiver Portal is required." Respondents must certify in capabilities statement that products are manufactured in the United States.

The purpose of this notice is to obtain information regarding the availability and capability of all U.S manufactured products that are equal to the following product:

We are seeking a EXO-NET Pan-Exosome Capture Beads, 1.0mL: a magnetic bead-based immunoaffinity ev capture device, tool for exosome isolation from plasma,  serum, urine, saliva and cell-conditioned medium. where a 3-dimensional antibody matrix is constructed on a carbon nanoparticle. The complement of antibodies attached to the bead has been designed to capture a

wide range of extracellular vesicles (EVs, including exosomes) from different cell types (pan-EV capture). EXO-NET is designed for On-Bead Analysis of captured nanoparticles and ON-Bead lysis for

downstream analysis of EV-associated molecules including proteins, oligonucleotides (mRNAs and microRNAs) and lipids. EXO-NET also can be tuned to preferentially isolate EVs from specific cell types. EXO-NET is a scalable EV isolation solution for high

throughput screening.

Product Composition

Component % (w/v):

Magnetic Beads 0.40%

Antibodies 0.05%

BS3 (bis(sulfosuccinimidyl)suberate) 0.07%

Proclin 300 0.01%

Halt Protease Inhibitor Cocktail 0.09%

DPBS without Ca and Mg (pH 7.4) 99.38

The essential specifications and capabilities needed are:

1. 40031 EXO-NET® Pan-Exosome Capture 1.0 mL, QTY of 12

Capability Statement/Information Sought

All capable vendors should respond with a brief capability statement demonstrating an equal product that is manufactured in the United States by July 29, 2024, by 10:00 AM EST.

Capabilities statement must also include the following information: 1) organization name, address, point of contact, email address, website address, telephone number, UE ID# with an active SAM.gov registration, and a tailored capability statements addressing the particulars of this effort, with appropriate documentation supporting claims of capability.

Submission Instructions

Interested businesses who consider themselves qualified to provide an equal product that is manufactured in the United States for the above-listed product are invited to submit a response to this Sources Sought Notice by July 29, 2024, by 10:00 AM EST. All responses under this Sources Sought Notice must be emailed to directly to, Kimberly Rubio: kimberly.rubio@nih.gov with the Sources Sought ID# SS-NIAID-24-2232555 in email the subject line.

Disclaimer and Important Notes

This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality

No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).