DRAGEN Iterative gVCF Genotyper (IGG) Caller

This is a Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding the availability and capability of all qualified sources to provide equipment for this requirement.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.  It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.  Responses will not be considered as proposals or quotes.  No award will be made as a result of this notice.  The Government will NOT be responsible for any costs incurred by the respondents to this notice.  This notice is strictly for research and information purposes only.

BACKGROUND INFORMATION AND OBJECTIVE:

Our project aims to enhance our understanding of neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), through the detailed analysis of human DNA samples using state-of-the-art, short-read whole-genome sequencing. We will conduct association analyses to map the genetic factors that contribute to these human diseases, which claim the lives of thousands of Americans each year. Our findings will shed light on the complex genetic landscape of neurodegeneration and ultimately provide targets for therapeutic development.

GENERIC NAME OF PRODUCT:

Illumina Integrated gVCF Genotype (IGG) caller

SALIENT CHARACTERISTICS:

Capable vendors must demonstrate their ability provide the following brand name or equal items:

• Must use the Illumina IGG caller to jointly call (i.e., merge) our existing single-sample gVCF files (n = 56,000).

• Must be capable of working with gVCFs that have been generated using the DRAGEN alignment pipeline (version 4.3).

• Must be able to retain the INFO and QUALITY CONTROL information embedded in the single-sample gVCF input files, for use in downstream filtering and analyses.
• Must be able to provide n+1 sample calling infrastructure, thereby allowing new samples to be added to a dataset without the need to reprocess the entire dataset from scratch each time.

QUANTITY: (Brand name or equal)

• DRAGEN Iterative gVCF Genotyper (DRAGEN IGG): No. 20071787. Qty. 14
• Illumina Analytics iCredit: No. 20042038. Qty. 19,600

INSTRUCTIONS:

Companies that believe they possess the capabilities to provide the required product should submit documentation of their ability to meet each of the requirements to the Contracting Officer. The capability statement must specifically address each of the requirements separately. All capability statements must also include the following: 1) company name and address; 2) point of contact; 3) phone/fax/email; 4) NAICS Code(s); 5) business size and status; 6) capability information in response to the requirement and qualifications identified in this notice; and 7) type of small business your organization classifies itself as (i.e.: Women-Owned, HUBZone, etc.).

Each capability statement must include the respondent’s Unique Entity Identifier number, organization name, and address. Each response should include the technical and administrative points of contact, including names, titles, addresses, telephone numbers, and e-mail addresses. The capability statement should clearly identify the size and type of business (e.g., 8(a), HubZone, Non-Profit, Other Than Small Business, etc.), pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

The information submitted must be in an outline format that addresses each of the elements of the project requirement and in the capability statement paragraphs stated herein.  A cover page and an executive summary may be included but is not required.

Any business concerns that believe they possess the capability necessary to successfully undertake the work described above must SUBMIT CAPABILITY STATEMENTS ELECTRONICALLY to the Contract Specialist, Shaun Rostad at Shaun.Rostad@nih.gov, NO LATER THAN 1:00 p.m. EST on July 31, 2025. The Subject line for the submission should include this Sources Sought Number and organization name. NIDA will not accept paper or faxed capability statements.

THIS NOTICE IS NOT A REQUEST FOR PROPOSALS.  This notice is for information and planning purposes only and does not commit the Government to any contractual agreement. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in SAM.gov. However, responses to this notice will not be considered adequate responses to a solicitation.

CONFIDENTIALITY. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).