DEVELOPMENT OF NOVEL MONOCLONAL ANTIBODIES AND LONGITUDINAL STUDY OF IMMUNE RESPONSES USING SERUM AND PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC’s) OF INFECTIOUS DISEASE SURVIVORS
Closed Solicitation Posted
This opportunity was awarded. See the award notice from .
- Solicitation number
- W81XWH-21-R-0074
- Agency
-
Medical Command
Department of the Army, Department of Defense
- Responses due
- Set-aside
- Total Small Business
Opportunity facts
- NAICS code
- 541380 Testing Laboratories and Services
- PSC
- Q301 Reference Laboratory Testing
- Place of performance
- Frederick, Maryland 21702, United States
Notice details come from SAM.gov. Updated .
About this opportunity
This solicitation seeks a contractor to identify cohorts of survivors of Crimean-Congo hemorrhagic fever virus, Old World hantaviruses, Lassa virus, and Yersinia pestis in Georgia, Sierra Leone, and Madagascar. The contractor will collect whole blood samples from these survivors every six months, isolate peripheral blood mononuclear cells within twelve hours of collection, and ship samples to the U.S. Army Medical Research Institute of Infectious Diseases within fourteen days. The Department of the Army Medical Command seeks these services to track B and T cell immune responses over time and characterize the protective human immune response. The response due date is August 26, 2021. Offerors must provide evidence of existing infrastructure in the specified countries and an active human subjects protocol to allow for immediate sample collection upon award.
This opportunity is set aside as a total small business. The place of performance will be Fort Detrick, Maryland as well as designated locations within Georgia, Sierra Leone, and Madagascar. The period of performance consists of one base year and four one-year options. Offerors must submit evidence of meeting organizational conflict of interest requirements and must have a technical approach for immediate initiation of sample collection within the specified countries upon award.
Notice text
2 versions
Update #2 · Latest ·
***SOLICITATION AMENDMENT #0001***
**Please See Enclosed Newly Uploaded Documents**
The Purpose of this Amendment is to:
1. Provide Answers to Questions.
2. Add the Organizational Conflict of Interest and the Non-Disclosure Statements as attachments to this Solicitation separately in accordance with new policy regulations.
3. Correct the CLIN Description's to show the proper location for each Blood Collection Site, and, update the Performance Work Statement as a result of questions asked by Offerors to this Solicitation.
4. All Other Terms and Conditions of this Amendment Remain Unchanged.
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The primary objective of this requirement is to identify and engage survivors of CCHFV and Old World Hantaviruses, LASV and Y. Pestis in Georgia, Sierra Leone and Madagascar respectively. Both B and T cell responses will be tracked over time to develop a picture of the protective immune response in humans. This study will involve collaboration with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).
Identify a cohort of survivors of CCHFV and Old World Hantaviruses (Georgia), LASV (Sierra Leone) and Y. Pestis (Madagascar) and perform whole blood collection. Blood samples will be delivered to the in-country host laboratory expeditiously following each collection. Peripheral Blood Mononuclear Cells (PBMC’s) must be isolated and stored at -80ºC within Twelve (12) Hours of collection.
Every six (±2) months, perform follow-up collection of survivor’s sera and lymphocyte samples (whole blood). Travel schedules will require coordination with USMARIID personnel.
Assist USAMRIID and/or host country personnel in blood processing and analysis as needed.
Ship blood products to laboratories at USAMRIID, or to collaborators, as needed. Shipments must occur within Fourteen (14) days of collections.
Contractor must provide evidence of pre-existing infrastructure within the countries identified to allow collections to occur immediately upon award of the contract.
Contractor must provide evidence of having an active human use protocol in countries to allow collections from survivors.
Update #1 ·
The primary objective of this requirement is to identify and engage survivors of CCHFV and Old World Hantaviruses, LASV and Y. Pestis in Georgia, Sierra Leone and Madagascar respectively. Both B and T cell responses will be tracked over time to develop a picture of the protective immune response in humans. This study will involve collaboration with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).
Identify a cohort of survivors of CCHFV and Old World Hantaviruses (Georgia), LASV (Sierra Leone) and Y. Pestis (Madagascar) and perform whole blood collection. Blood samples will be delivered to the in-country host laboratory expeditiously following each collection. Peripheral Blood Mononuclear Cells (PBMC’s) must be isolated and stored at -80ºC within Twelve (12) Hours of collection.
Every six (±2) months, perform follow-up collection of survivor’s sera and lymphocyte samples (whole blood). Travel schedules will require coordination with USMARIID personnel.
Assist USAMRIID and/or host country personnel in blood processing and analysis as needed.
Ship blood products to laboratories at USAMRIID, or to collaborators, as needed. Shipments must occur within Fourteen (14) days of collections.
Contractor must provide evidence of pre-existing infrastructure within the countries identified to allow collections to occur immediately upon award of the contract.
Contractor must provide evidence of having an active human use protocol in countries to allow collections from survivors.
Files
Notice history
| Notice | Type | Posted |
|---|---|---|
| DEVELOPMENT OF NOVEL MONOCLONAL ANTIBODIES AND LONGITUDINAL STUDY OF IMMUNE RESPONSES USING SERUM AND PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC’s) OF INFECTIOUS DISEASE SURVIVORS | Award Notice | |
| This notice | Solicitation | |
| GeneMapper ID-X | Special Notice |
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