Compound Discoverer and Proteome Discoverer Software

This Request for Information (RFI)/Sources Sought (SS) Notice is for market research, information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the Walter Reed Army Institute of Research (WRAIR) or the US Army Medical Research Acquisition Activity (USAMRAA). The requested information is for Compound Discoverer and Proteome Discoverer Software for the Medical Readiness Systems Biology Branch, located at 503 Robert Grant Ave, Silver Spring, Maryland.

At a minimum the Compound Discoverer and Proteome Discoverer Software shall include the following:

Compound Discover:

• Integrated, complete, toolset solves mass spectroscopy data generated from high resolution accurate-mass (HRAM) Thermo Scientific™ instruments, such as the Orbitrap ID-X™, Orbitrap Fusion™, Orbitrap™ hybrids, Q Exactive™, and Exactive™ mass spectrometers.
• Increase certainty using multi-factorial Peak Quality scoring, determine elemental composition, separate co-eluting components, and gain confidence in ID with automated MSn tree search.
• Automatically search spectral libraries, annotate spectra, query chemical databases for putative candidates
• Perform differential statistical analysis and mine data deeper with multivariate statistical analysis. Customizable data visualization.
• Data processing with its customizable workflows.

Proteome Discoverer:

• Software for peptide and protein identification, post translational modification analysis, isobaric mass tagging, and label-free quantitation from data-independent, data-dependent, and wide window acquisitions.
• Analysis of glycopeptides, top-down proteomics, proteoform analysis.
• Comprehensive data analyses through supporting multiple database search algorithms and dissociation techniques.
• Data processing with its customizable workflows.

This announcement is not a formal solicitation and is not a request for proposal. No contract will be awarded from this announcement. No reimbursement will be made of any costs to provide information in response to this announcement or any follow up information requests. Availability of any formal solicitation will be announced under a separate announcement. This synopsis is for market research, information and planning purposes only and is not to be construed as a commitment by the Government. Each response must reference the sources sought title. All proprietary information should be marked as such. Responses will be held confidential if requested.

RFI Response and due date: 06 June 2024 10:00AM ET

Instructions to Responders:

Responses from all capable and qualified sources are encouraged to respond to this request.

White papers should adhere to the following formatting and outline instructions:

1. All submissions shall be made electronically and be in one of the following formats: Microsoft Word or Adobe PDF.

2. Cover Page (1page)

· Title

· Organization

· Responders technical and administrative points of contact (names, addresses, phone, fax number and email addresses)

· Topic area(s) addressed

3. Please note that the response shall provide sufficient technical data to determine how you fully meet the requirements as specified.

Please note that responses are due no later than 06 June 2024 10:00PM ET. The preferred method of submission is via email. The point of contact for this action is Ms. Flodean Billings, Contract Specialist flodean.p.billings.civ@health.mil . Only electronic responses are requested. No evaluation letters and/or results will be issued to the respondents. At this time no solicitation exists; therefore, please do not request a copy of the solicitation.