Cisbio Pro-Collagen Type 1 (Human) Kits and Alpha-SMA Assay Kits, brand name or equal

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.
Please note that to qualify as an eligible small business for purposes of a small business set-aside, at least 50% of the cost of contract performance incurred for personnel must be expended for employees of the small business awardee (see FAR 52.219-14 Limitations on Subcontracting).
Purpose and Objectives
The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The National Center for Advancing Translational Sciences (NCATS) is a translational science center that prides itself on its tremendously productive pipeline and is innovative in several ways. NCATS brings together a diverse range of scientists, including medicinal chemists, biologists, toxicologists, and engineers, in to ultimately translate basic science into real products and services that help improve people's lives.
NCATS is working on a TRND Relaxin FIU project which has as goal to perform medicinal chemistry to measure type 1 collagen in a human cell line as a marker for inflammation. The Cisbio Pro-collagen type 1 (human) and Alpha-SMA assay kits are needed for this project.
Project Requirements
NCATS seeks to purchase twelve (12) assay kits: six (6) Pro-collagen Type 1 (human) kits and six (6) Alpha-SMA kits. NCATS seeks the below kits, or brand-name equal kits.
1. Pro-Collagen Type 1 (Human) kits
Quantity: six (6)
Manufacturer: Cisbio
Product Code: 63ADK014PEH
Salient Characteristics:
• Sandwich immunoassay detecting human pro-collagen type 1
• Detectable in a sandwich assay format using two (2) different specific monoclonal antibodies, one labeled with Europium Cryptate (donor) and the second with d2 (acceptor)
• Allows detection of human pro-collagen type 1 in cell supernatants
• Allows quantification of human pro-collagen type 1 in cell supernatants
• Allows functional screening of compounds using Human pro-collagen type 1 secreting cells
• Allows for low volume sample size needed
• Good for live cell, supernatant, and biochemical-based protocols
• Comes as all-in-one ready to use kit with no necessity of additional purchase of components to make it work
Ideally it will come with a simple "add & read" protocol, no washing step.
2. Alpha-SMA assay kits
Quantity: six (6)
Manufacturer: Cisbio
Product Code: 62ASMAPEH
Salient Characteristics:
• Cell-based and able to measure expression level of alpha-SMA tissue fibrosis
• Specific for alpha-SMA isoforms
• Compatible with both human and mouse species
• Able to identify anti-fibrotic compounds
• Has high sensitivity, preferably at the endogenous level of alpha-SMA in LX-2 cell lines
• Optimized for 96- and 384-well plates protocol
• Good to run in both frozen cell lysates and/or fresh cell lines
Anticipated Period of Performance
Delivery of the kits is to occur within thirty (30) days after receipt of order.
Required Information
All capability statements must provide the following: (1) DUNS number; (2) organization name; (3) organization address; (4) point of contact; (5) point of contact title, address, telephone, and email address; and (6) size and type of business (e.g., 8(a), HUBZone, etc.) pursuant the applicable NAICS code.
Submission Instructions and Due Date
Written capability statements must be SUBMITTED NO LATER THAN 12:00PM EDT ON FRIDAY, DECEMBER 14, 2018 to the below Contracting Office Address, Attn: Kimberly Espinosa. Electronic capability statements will be accepted by the primary point of contact listed below.
Disclaimer and Important Notes
This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.
Confidentiality
No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
Contracting Office Address
NCATS Section
NIDA Office of Acquisition
6001 Executive Boulevard
Suite 3151, MSC 9531
Bethesda, Maryland 20892-9531*
*Use Rockville, MD 20852 for Fed-Ex/USPS/Courier/Hand-Delivery
Points of Contact
Primary Point of Contact:
Kimberly Espinosa
Contract Specialist
Kimberly.espinosa@nih.gov
Phone: (301) 827-3546.