Chemical library of 2, 500 - 2, 600 small molecule compounds distributed across specified chemical scaffolds

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.
(ii) The solicitation number is 75N95019Q00181 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold.
(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2019-02, dated June 5, 2019.
(iv) The associated NAICS code is 325414 and the small business size standard is 1,250 employees. This requirement is full and open with no set aside restrictions.
Description
(v) NCATS seeks to purchase one (1) chemical library of 2,500 - 2,600 small molecule compounds that are distributed across specified chemical scaffolds* or chemotypes. This chemical library is needed for NCATS' Genesis screening libraries. Adding diversity to chemical libraries is imperative to NCATS' operation as it screens a variety of targets against these in-house collections.
The requirements of this chemical library include:
1. The library must contain at least 2,500 and no more than 2,600 compounds.
2. All scaffolds* must be represented in the compound library.
3. Each compound must be unique and contain one of the required scaffolds.
4. Each compound must be provided at 2mg quantity.
5. Each compound must have a purity of >90% (accuracy +/-5%) that is to be confirmed by NMR and/or LCMS spectra.
6. Each compound must be provided in 2D barcoded Micronic tubes as 2mg of dry film in each tube.
7. The compound library must conform to drug-like parameters such as distribution of molecular weight, solubility, lipophilicity, hydrogen bond donors and acceptors.
8. The compounds must be replenishable. They must be available for resupply or resynthesis if needed for NCATS follow up in the future.
9. The contractor must also provide all of the following information electronically for each required molecule, referencing individual compound vial barcodes:
• chemical structure or simplified molecular-input line-entry system (SMILES) or equivalent chemical structure information
• supplier ID
• plate ID
• well location
• tube ID
* See the attached list of specific scaffolds
(vi) Delivery is to occur within 12 weeks after receipt of order. Delivery shall be made to the below address with FOB Destination. A specific point of contact will be indicated on the purchase order.

National Center for the Advancement of Translational Sciences
9800 Medical Center Drive
Rockville, MD 20850
(vii) The Government plans to award a contract resulting from this solicitation. The resulting award will be made to the responsible offeror whose offer will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate quotations: Technical Capability, Past Performance, and Price. Comparative evaluations will be conducted.
(viii) The anticipated award date is July 17, 2019.
Provisions and Clauses

(ix) The provision at FAR 52.252-1, Solicitation Provisions Incorporated by Reference (Feb 1998). This solicitation incorporates one or more solicitation provisions by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. The offeror is cautioned that the listed provisions may include blocks that must be completed by the offeror and submitted with its quotation or offer. In lieu of submitting the full text of those provisions, the offeror may identify the provision by paragraph identifier and provide the appropriate information with its quotation or offer. Also, the full text of a solicitation provision may be accessed electronically at this/these address(es): www.acquisition.gov.
The following provisions apply to this acquisition and are incorporated by reference:

• The provision at FAR 52.204-7, System for Award Management (Oct 2018)
• The provision at FAR 52.204-16, Commercial and Government Entity Code Reporting (Jul 2016)
• The provision at FAR 52.212-1, Instructions to Offerors - Commercial Items (Oct 2018)
• The provision at 52.212-3, Offeror Representations and Certifications-Commercial Items (Oct 2018)
(x) The clause at FAR 52.252-2, Clauses Incorporated by Reference (Feb 1998). This contract incorporates one or more clauses by reference, with the same force and effect as if they were given in full text. Upon request, the Contracting Officer will make their full text available. Also, the full text of a clause may be accessed electronically at this/these address(es): www.acquisition.gov.
The following clauses apply to this acquisition and are incorporated by reference:

• The clause at FAR 52.204-13, System for Award Management Maintenance (Oct 2018)
• The clause at FAR 52.204-18, Commercial and Government Entity Code Maintenance (Jul 2016)
• The clause at FAR 52.212-4, Contract Terms and Conditions - Commercial Items (Oct 2018)
• The clause at HHSAR 352.222-70, Contractor Cooperation in Equal Employement Opportunity Investigations (December 18, 2015)
(xi) The following provisions and clauses apply to this acquisition and are attached in full text:

• Addendum to the clause at FAR 52.212-4, Contract Terms and Conditions - Commercial Items (Oct 2018)
• The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items (May 2019)
• NIH Invoice and Payment Provisions (2/2014)
(xii) There are no additional contract requirement(s) or terms and conditions applicable to this acquisition.
(xiii) The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement.
(xiv) Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product or service. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, product or catalog number(s); product description; what the warranty covers; and any other information or factors that may be considered in the award decision. Such factors may include but are not limited to: past performance, special features required for effective program performance, warranty considerations, and environmental and energy efficiency considerations.
The Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by 11:59am EDT on Friday, July 12, 2019, and reference solicitation number 75N95019Q00181. Responses must be submitted via email to Kimberly Espinosa, Contract Specialist, at kimberly.espinosa@nih.gov, with a copy to Jeff Schmidt, Contracting Officer, at schmidtjr@mail.nih.gov.
(xv) The name and telephone number of the individual to contact for information regarding the solicitation is Kimberly Espinosa, Contract Specialist, 301-827-3546 kimberly.espinosa@nih.gov.
(xvi) All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency.

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