Advanced Multichannel Multispectral Photodetection System
Closed Pre-Solicitation Posted
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- Solicitation number
- NIST-AMD-PML-SSN-26-06
- Agency
- National Institute of Standards and Technology Department of Commerce
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 334516 Analytical Laboratory Instrument Manufacturing
- Place of performance
- Gaithersburg, Maryland 20899, United States
- Points of contact
-
- Robert Singman robert.singman@nist.gov (301) 975-6388
Notice details come from SAM.gov. Updated .
About this opportunity
NIST is preparing to procure an advanced multichannel multispectral photodetection system for integration into its Serial Flow Cytometer, with a sources sought notice due by June 12, 2026. This is market research only and does not constitute a commitment to solicit or award.
The photodetector system must perform multispectral light detection across 16 non-overlapping spectral channels (20 nm width distributed across 450–750 nm wavelength range) from four light sources, each accepting one SMA905 fiber optic input (NA 0.1, core diameter 105 μm). Detectors must utilize photomultiplier tubes, avalanche photodiodes, silicon photomultipliers, or hybrid formats. Performance specifications include typical peak photon detection efficiency of 10%, net bandwidth 500 kHz, readout noise 10 mV peak-to-peak, dynamic range 10,000, and maximum voltage output 500 mV to 10 V with SMA or BNC connectors. The system requires integrated power supply, tunable amplification gain (hardware or computer-controlled), and gain range sufficient to resolve fluorescence intensities between 102 and 105 MESF.
Place of performance is NIST's Biophysical and Biomedical Measurement Group, Microsystems and Nanotechnology Division, Physical Measurement Laboratory. Responses are limited to four pages and must include company information, specific equipment details with manufacturer and model number, technical specifications, country of manufacturing, performance capabilities, customization options, manufacturing location, small business classification, available services (installation, training, maintenance), standard terms and conditions, and customer references. Submit by email to the points of contact listed in the notice (NIST-AMD-PML-SSN-26-06).
Notice text
The National Institute of Standards and Technology (NIST), Biophysical and Biomedical Measurement Group (BBMG) within the Microsystems and Nanotechnology Division of the Physical Measurement Laboratory (PML) requires an advanced spectral photodetection system for incorporation into NIST’s unique and world-class Serial Flow Cytometer for high temporal and spectral resolution optical measurements of biological micro and nanoparticles. This will enable accomplishment of our mission of developing microscale measurement science and technology applied to characterization of biological systems.
Flow cytometry is a technology that rapidly analyzes properties of thousands of single cells or particles per second as they flow in a fluid stream. A laser incident on the fluid stream interrogates the cells, which can be labeled with fluorescent markers to enable the quantification of specific cell markers and classification of different cell types within populations. NIST develops a Serial Flow Cytometer (SFC) that uses multiple light sources to repeat optical measurements of single cells to provide uncertainty quantification (UQ). UQ is a valuable outcome that enables optimization of flow cytometers and modeling to improve confidence in flow cytometry measurements and instrument comparability.
NIST requires a complete, multichannel and multispectral photodetector system as listed below in the Scope and specified below in Minimum Requirements. The system will integrate directly into NIST’s Serial Flow Cytometer to perform sensitive, dynamic, and hyperspectral fluorescence measurements of rapidly flowing micro and nanoparticles including cells, gene therapy nanoparticles, and fluorescence calibration particles. Incorporation of the system within NIST instruments requires compatible connections to optical lines and routing of voltage signals to NIST recording devices.
The advanced photodetector system is critical to achieve NIST project missions as it will enable the R&D team to build generalizable, multimodal cytometric tools with world-class deep spectral probing to advance Critical and Emerging Technologies (CETs) in Biotechnology.
Attachments
| File | Type | Posted |
|---|---|---|
| 09-Sources Sought Notice-Photodetector System.pdf |
Notice history
| Notice | Type | Posted |
|---|---|---|
| Advanced Multichannel Multispectral Photodetection System | Solicitation | |
| Advanced Multichannel Multispectral Photodetection System | Pre-Solicitation |
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